有机化学 ›› 2021, Vol. 41 ›› Issue (7): 2810-2819.DOI: 10.6023/cjoc202102037 上一篇    下一篇

研究论文

铜催化合成2-亚氨基-1,2-二氢喹啉化合物

祝改革, 赖晓辉, 王思雨, 林彩霞*(), 袁耀锋*()   

  1. 福州大学化学学院 福州 350108
  • 收稿日期:2021-02-21 修回日期:2021-03-23 发布日期:2021-04-12
  • 通讯作者: 林彩霞, 袁耀锋
  • 基金资助:
    国家自然科学基金(21772023); 国家自然科学基金(22071025)

Synthesis of 2-Imino-1,2-dihydroquinolines via Copper Catalysis

Gaige Zhu, Xiaohui Lai, Siyu Wang, Caixia Lin(), Yaofeng Yuan()   

  1. College of Chemistry, Fuzhou University, Fuzhou 350108
  • Received:2021-02-21 Revised:2021-03-23 Published:2021-04-12
  • Contact: Caixia Lin, Yaofeng Yuan
  • Supported by:
    National Natural Science Foundation of China(21772023); National Natural Science Foundation of China(22071025)

报道了室温条件下磺酰叠氮、2-氨基苯甲醛、末端炔烃通过一价铜催化合成2-亚氨基-1,2-二氢喹啉化合物的方法. 该反应条件温和, 具有较好的底物普适性, 当更改底物炔烃的类型时, 可以选择控制不同产物的合成, 包括二氢喹啉和N-磺酰脒类化合物.

关键词: 2-亚氨基-1, 2-二氢喹啉, 三组分反应, 磺酰叠氮, 炔烃

A mild three-component method for the synthesis of 2-imino-1,2-dihydroquinoline compounds has been successfully developed. In the presence of CuCl, various terminal alkynes, sulfonyl azides and 2-aminobenzaldehydes were coupled. When changing the type of substrate alkyne, controlled synthesis of dihydroquinoline and sulfonyl amidine compounds were achieved.

Key words: 2-imino-1, 2-dihydroquinoline, three-component synthesis, sulfonyl azides, alkynes