有机化学 ›› 2021, Vol. 41 ›› Issue (8): 3015-3033.DOI: 10.6023/cjoc202012036 上一篇    下一篇

综述与进展

基于靶标结构及作用机制的抗艾滋病药物研究进展

陈超a,b, 胡晓东b, 王春喜b, 蓝文贤b, 吴小余a,*(), 曹春阳b,*()   

  1. a 上海大学理学院化学系 上海 200444
    b 中国科学院上海有机化学研究所 生命有机化学国家重点实验室 上海 200032
  • 收稿日期:2020-12-22 修回日期:2021-03-12 发布日期:2021-04-29
  • 通讯作者: 吴小余, 曹春阳
  • 基金资助:
    科技部重点研发(2017YFE0108200); 科技部重点研发(2016YFA0502302); 中国科学院战略性先导科技专项(XDB20000000); 国家自然科学基金(21778065); 国家自然科学基金(21807105); 国家自然科学基金(21977110); 国家自然科学基金(91753119)

Structure- and Mechanism-Based Research Progress of Anti-acquired Immune Deficiency Syndrome Drugs

Chao Chena,b, Xiaodong Hub, Chunxi Wangb, Wenxian Lanb, Xiaoyu Wua(), Chunyang Caob()   

  1. a College of Science, Shanghai University, Shanghai 200444
    b State Key Lab of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2020-12-22 Revised:2021-03-12 Published:2021-04-29
  • Contact: Xiaoyu Wu, Chunyang Cao
  • Supported by:
    National Key Research and Development Program of Ministry of Science and Technology(2017YFE0108200); National Key Research and Development Program of Ministry of Science and Technology(2016YFA0502302); Chinese Academy of Sciences Strategic Priority Research Program(XDB20000000); National Natural Science Foundation of China(21778065); National Natural Science Foundation of China(21807105); National Natural Science Foundation of China(21977110); National Natural Science Foundation of China(91753119)

人体免疫缺陷病毒(Human immunodeficiency virus, HIV)是一种主要以CD4+T淋巴细胞和巨噬细胞等免疫细胞为靶点的感染性逆转录病毒, HIV感染的最终阶段为出现获得性免疫缺陷综合征(Acquired immunodeficiency syndrome, AIDS). HIV迄今为止已经夺去近3300万人生命, 是全球最大的公共卫生挑战之一. 自从抗逆转录病毒治疗(Antiretrovial therapy, ART)出现以后, 抗逆转录药物的联合使用使艾滋病从致死性疾病变成慢性可控性疾病. 为了开发新的抗艾滋病药物, 基于病毒复制周期中的不同靶标将近年发展的抗艾滋病药物进行分类简述, 重点关注于药物的作用机制研究、临床应用现状及未来发展方向.

关键词: 抗逆转录病毒药物, 人体免疫缺陷病毒, 获得性免疫缺陷综合征, 长效抑制剂

Human immunodeficiency virus (HIV) is a retrovirus that mainly targets immune cells such as CD4+T lymphocytes and macrophages, which eventually leads to acquired immunodeficiency syndrome (AIDS). HIV continues to be a major global public health challenege, having killed almost 33 million lives so far. Since the emergence of antiretroviral therapy (ART), the combination of antiretroviral drugs has transformed HIV-1 infection, once a fatal illness, into a manageable chronic condition. Based on different targets during the virus replication cycle, anti-AIDS drugs in recent years were classified with focus on the mechanism elucidation, current clinical application and future direction.

Key words: antiretroviral drug, human immunodeficiency virus (HIV), acquired immune deficiency syndrome (AIDS), long-acting inhibitor