有机化学 ›› 2022, Vol. 42 ›› Issue (5): 1438-1442.DOI: 10.6023/cjoc202110005 上一篇    下一篇

研究论文

I2/叔丁基过氧化氢(TBHP)促进烯烃和N,N-二甲基甲酰胺的氧化-酰胺化反应: 一种制备芳基-α-酮酰胺衍生物的简易方法

肖朵朵a, 刘海灵b, 周鹏a, 张建涛a,*(), 刘卫兵a,*()   

  1. a 广东石油化工学院化学学院 广东茂名 525000
    b 北京师范大学分析测试中心 北京 100875
  • 收稿日期:2021-10-05 修回日期:2022-01-17 发布日期:2022-02-10
  • 通讯作者: 张建涛, 刘卫兵
  • 基金资助:
    广东省普通高校青年创新基金(2018KQNCX167); 广东石油化工学院人才引进计划(2017rc07); 广东石油化工学院人才引进计划(2019rc048); 广东石油化工学院创新研究团队(519124)

I2/t-Butylhydroperoxide (TBHP)-Mediated Oxo-amidation of Alkenes with N,N-Dimethylformamide: A Facile Access to Aryl-α-ketoamide Derivatives

Duoduo Xiaoa, Hailing Liub, Peng Zhoua, Jiantao Zhanga(), Weibing Liua()   

  1. a College of Chemistry, Guangdong University of Petrochemical Technology, Maoming, Guangdong 525000
    b College Analytical and Testing Centre, Beijing Normal University, Beijing 100875
  • Received:2021-10-05 Revised:2022-01-17 Published:2022-02-10
  • Contact: Jiantao Zhang, Weibing Liu
  • Supported by:
    Ordinary University Young Innovative Talents Project of Guangdong Province(2018KQNCX167); Projects of Talents Recruitment of Guangdong University of Petrochemical Technology(2017rc07); Projects of Talents Recruitment of Guangdong University of Petrochemical Technology(2019rc048); Program for Innovative Research Team of Guangdong University of Petrochemical Technology(519124)

N,N-二甲基甲酰胺(DMF)为溶剂和二甲胺源, 发展了用于合成芳基-α-酮酰胺衍生物的烯烃双官能化反应. 该过程采用I2/叔丁基过氧化氢(TBHP)为催化氧化体系, 一系列芳基-α-酮酰胺衍生物以良好的收率合成得到.

关键词: 氧化-酰胺化, 烯烃, N,N-二甲基甲酰胺, 芳基-α-酮酰胺

Difunctionalization of alkenes providing for the synthesis of aryl-α-ketoamide derivatives is developed by using N,N-dimethylformamide (DMF) as the solvent and the source of dimethylamine. This procedure is catalyzed by I2 and t-butylhydroperoxide (TBHP) as oxidant. A wide range of aryl-α-ketoamide derivatives are generated in good yields.

Key words: oxo-amidation, alkenes, N,N-dimethylformamide, aryl-α-ketoamide