有机化学 ›› 2023, Vol. 43 ›› Issue (3): 1023-1035.DOI: 10.6023/cjoc202211032 上一篇    下一篇

所属专题: 中国女科学家专辑

综述与进展

镍催化不对称酰基化反应研究进展

张妍妍, 张珠珠, 朱圣卿*(), 储玲玲*()   

  1. 东华大学化学与化工学院 先进低维材料中心 上海 201620
  • 收稿日期:2022-11-27 修回日期:2023-01-02 发布日期:2023-01-11
  • 通讯作者: 朱圣卿, 储玲玲
  • 基金资助:
    国家自然科学基金(21971036); 国家自然科学基金(21901036)

Recent Advances in Nickel Catalyzed Asymmetric Acylation Reactions

Yanyan Zhang, Zhuzhu Zhang, Shengqing Zhu(), Lingling Chu()   

  1. Center for Advanced Low-Dimension Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620
  • Received:2022-11-27 Revised:2023-01-02 Published:2023-01-11
  • Contact: Shengqing Zhu, Lingling Chu
  • Supported by:
    National Natural Science Foundation of China(21971036); National Natural Science Foundation of China(21901036)

α-手性羰基化合物是天然产物和药物中的重要结构单元, 也是反应性最为丰富的重要合成中间体. 过渡金属催化不对称酰基化反应是构建该重要结构单元的高效方法之一, 近些年来, 具有独特催化活性的丰产金属镍催化剂也被广泛应用于不对称羰基化合物的合成. 综述了近些年来镍催化不对称酰基化反应领域的新研究进展, 主要包括镍催化不对称烷基-酰基偶联反应、烯烃不对称氢酰基化反应以及烯烃不对称酰基官能团化反应等.

关键词: 镍催化, 不对称酰基化, 氢酰基化, 烯烃

Chiral αα-carbonyl compounds are important structural units in natural products and pharmaceuticals and versatile synthetic building blocks in organic synthesis. Transition metal-catalyzed asymmetric acylation reaction is one of the most straightforward methods for preparing these compounds. In particular, significant progress has been made in the area of nickel-catalyzed asymmetric acylation reaction, due to the unique properties of nickel catalysts. The latest progress of nickel-catalyzed asymmetric acylation reaction, including nickel-catalyzed asymmetric alkyl-acyl cross-coupling reaction, asymmetric hydroacylation of alkene and asymmetric acyl-functionalization alkene, is summarized.

Key words: nickel catalysis, asymmetric acylation, hydroacylation, alkene