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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (4): 433-437. 上一篇    下一篇

研究简报

梯形结构有机锡化合物二{氧合-二[2-吡啶甲酸二丁基锡(IV)]}的合成、性质和晶体结构

尹汉东*,a, 周广连a, 刘国富b   

  1. a聊城大学化学系 聊城 252059
    b聊城大学生物系 聊城 252059
  • 收稿日期:2003-07-07 修回日期:2003-09-08 接受日期:2003-10-14 发布日期:2022-09-19
  • 基金资助:
    国家自然科学基金(No. 20271025)、教育部骨干教师基金和山东省自然科学基金(No. Y2001B02)资助项目

Synthesis, Properties and Crystal Structure ofthe Ladder Organotin Compound Bis{oxo-bis[(2-pyridinecarboxylato)dibutyltin(IV)]}

YIN, Han-Dong*,a, ZHOU, Guang-Liana, LIU, Guo-Fub,   

  1. aDepartment of Chemistry, Liaocheng University, Liaocheng 252059
    bDepartment of Biology, Liaocheng University, Liaocheng 252059
  • Received:2003-07-07 Revised:2003-09-08 Accepted:2003-10-14 Published:2022-09-19
  • Contact: *E-mail: handongyin@163.com

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用二丁基氧化锡与2-吡啶甲酸反应,合成了二{氧合-二[2-吡啶甲酸二丁基锡(IV)]},并进行了元素分析、红外光谱、核磁共振锡谱表征.X射线单晶衍射分析表明,化合物是以Sn2O2四面体为中心的,中心对称的二聚体结构,内环锡为五配位的畸变三角双锥构型,外环锡为六配位的畸变八面体结构.生物活性测试结果表明,该配合物具有较强的体外抗癌活性.

关键词: 有机锡, 2-吡啶甲酸, 合成, 晶体结构

Bis{oxo-bis[(2-pyridinecarboxylato)dibutyltin(IV)]} was synthesized by the reaction of 2-pyridinecarboxylic acid with dibutyltin(IV) oxide. The compound was tested against two human tumour cell lines: MCF-7 and WiDr. The results showed that this compound had higher activities in vitro. The compound has been characterized by elemental analysis, IR and 119Sn NMR and determined by X-ray single crystal diffraction. The compound isin centrosymmetric dimer structure mode with a four-member central endo-cyclic Sn2O2 unit in which the bridging oxygen atoms are tri-coordinated. Each bridging oxygen atom also connects with an exo-cyclic tin atom. The endo-cyclic tin atoms are five-coordinated with geometry of distorted trigonalbipyramid, while the exo-cyclic tin atoms are six-coordinated with geometry of distorted octahedron.

Key words: organotin, 2-pyridinecarboxylic acid, synthesis, crystal structure