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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (12): 1606-1609. 上一篇    下一篇

研究简报

N-取代苯基-N′-(1,3,4-噻二唑-2-基)脲类化合物的合成与生物活性

汪焱钢*,a, 王子云b, 赵新筠c, 宋新建a   

  1. a华中师范大学化学学院 武汉 430079
    b周口师范学院化学系 周口 466000
    c南阳师范学院化学系 南阳 473000
  • 收稿日期:2004-03-12 修回日期:2004-06-14 接受日期:2004-06-14 发布日期:2022-09-20
  • 基金资助:
    江苏省青蓝工程基金(No. QL98001)和江苏省高校自然科学基金(No. 04KJB150139)资助项目

Synthesis and Biological Activity of N-Substitutedphenyl- N′-(1,3,4-thiodiazol-2-yl)ureas

WANG Yan-Gang*,a, WANG Zi-Yunb, ZHAO Xin-Yunc, SONG Xin-Jiana   

  1. aCollege of Chemistry, Central China Normal University, Wuhan 430079
    bDepartment of Chemistry, Zhoukou Normal University, Zhoukou 466000
    cDepartment of Chemistry, Nanyang Normal University, Nanyang 473000
  • Received:2004-03-12 Revised:2004-06-14 Accepted:2004-06-14 Published:2022-09-20
  • Contact: *E-mail: xswang1974@yahoo.com or xswang@xznu.edu.cn

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通过酰基叠氮化物与2-氨基噻二唑或5-氨基-2-巯基噻二唑反应,合成了10个新的N-取代苯基-N′-(1,3,4-噻二唑-2-基)脲,用核磁共振氢谱、红外光谱和元素分析确证了它们的结构,初步的生测活性试验表明,部分目标化合物2c, 2d具有良好的细胞分裂素活性.

关键词: 噻二唑, 脲, 合成, 细胞分裂素, 生物活性

Ten new N-substituted phenyl-N′-(1,3,4-thiodiazol-2-yl)ureas have been synthesized by the reaction of acylazides with 2-amino-1,3,4-thiodiazole or 5-amino-2-mercapto-1,3,4-thiodiazole. Their structures have been confirmed by 1H NMR, IR spectra and elemental analysis. Preliminary biological activity tests show that some of the target compounds (2c and 2d) have the same good activity as cytokinin.

Key words: thiodiazole, urea, synthesis, cytokinin, biological activity