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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (7): 802-805. 上一篇    下一篇

研究论文

N-(2-吡咯甲酰基)氨基酸甲酯的合成

曾向潮a,b, 徐石海b, 李毅群b, 施文兵a, 邓芹英*,a   

  1. a中山大学化学与化学工程学院 广州 510275
    b暨南大学化学系 广州 510632
  • 收稿日期:2003-12-23 修回日期:2004-03-18 接受日期:2004-04-28 发布日期:2022-09-20
  • 通讯作者: *E-mail: ceslgk@zsu.edu.cn
  • 基金资助:
    国家863青年基金(No. 2001AA628100)和广东省自然科学基金(No. 31920)资助项目.

Synthesis of N-(Pyrrole-2-carbonyl)-amino Acid Methyl Esters

ZENG, Xiang-Chaoa,b, XU, Shi-Haib, LI, Yi-Qunb, SHI, Wen-Binga, DENG, Qin-Ying*,a   

  1. a School of Chemistry and Chemical Engineering, Sun Yat-sen University,Guangzhou 510275
    b Department of Chemistry, Jinan University, Guangzhou 510632
  • Received:2003-12-23 Revised:2004-03-18 Accepted:2004-04-28 Published:2022-09-20

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在室温条件下,氨基酸甲酯和2-三氯乙酰基吡咯经酰基化反应,以80.3%～95.6%的产率合成了系列N-(2-吡咯甲酰基)氨基酸甲酯,通过1H NMR, IR, MS和元素分析对其结构进行了表征.

关键词: N-(2-吡咯甲酰基)氨基酸甲酯, 2-三氯乙酰基吡咯, 氨基酸甲酯, 酰基化反应

A series of N-(pyrrole-2-carbonyl)-amino acid methylesters were synthesized by acylation of amino acid methyl esters with 2-(trichloroacetyl)pyrroles, without using pyrrole-2-carbonyl chloride as an acylatingagent, at room temperature in 80.3%～95.6% yields. And the structures of products were determined on the basis of 1H NMR, IR, MS and elementalanalyses.

Key words: N-(pyrrole-2-carbonyl)-amino acid methyl ester, 2-(trichloroacetyl)pyrrole, amino acid methyl ester, acylation