SIOC English
有机化学
高级检索

有机化学 ›› 2004, Vol. 24 ›› Issue (7): 806-810. 上一篇    下一篇

研究论文

中间锦鸡儿中的倍半萜类化合物

孙智华, 张甦, 施蛟, 胡昌奇*   

  1. 复旦大学药学院天然药物化学教研室 上海 200032
  • 收稿日期:2004-04-28 修回日期:2004-05-07 接受日期:2004-05-18 发布日期:2022-09-20
  • 通讯作者: *E-mail: changqihu@online.sh.cn; Fax: (021) 54237079.
  • 基金资助:
    国家自然科学基金(No. 30070085)资助项目

Sesquiterpenes from Caragana Intermedia

SUN, Zhi-Hua, ZHANG, Su, SHI, Jiao, HU, Chang-Qi*   

  1. Department of Chemistry of Natural Products, School of Pharmacy, Fudan University, Shanghai 200032
  • Received:2004-04-28 Revised:2004-05-07 Accepted:2004-05-18 Published:2022-09-20

PDF

100

从中间锦鸡儿(Caragana intermedia)地上部分分离得到二个新的倍半萜类化合物,即桉烷-4(15)-烯-1β,8α-二醇(1)和反式-八氢茚-7β-异丙基-4-亚甲基-9β-甲基-1β-醇(2),其中化合物2为桉烷类化合物中一种新的碳架;四个已知化合物,即异香木兰烷-3β,9β-二醇(3), (+)-3α,9β-香木兰烷二醇(4),　(+)-spathulenol (5)和(+)-lariciresinol (6).制备了以及化合物5的衍生物(+)-10α-溴-spathulenol (7).其中化合物1, 2, 3, 4, 5, 7分别在38, 10, 25, 18, 9, 35 μg/mL浓度时对稻瘟霉P-2b有完全抑制作用.以上分得的化合物及衍生物通过1D, 2D核磁共振、高分辨质谱、红外等光谱方法确定结构,其中化合物4通过X单晶衍射对其结构进行了进一步确证.

关键词: Caragana intermedia, 倍半萜, 茚, 桉烷

Two novel sesquiterpenoids, eudesm-4(15)-ene-1β,8α-diol (1) and trans-octahydroindane-7β-isopropyl-4-methylene-9β-methyl-1β-ol (2), four known compounds, alloaromadendrane-3α,9α-diol (3), (+)-3α,9β-aromaden-dranediol (4), (+)-spathulenol (5) and (+)-lariciresinol (6), were isolated from an aerial partof Caragana intermedia. (+)-10α-Bromospathulenol (7) was prepared from compound 5. Compounds 1, 2, 3, 4, 5 and 7 showed anti-pyriculariaoryzae P-2b activity with MIC value of 38, 10, 25, 18, 9 and 35 μg/mL,respectively. The structures of these compounds were determined by spectral dataincluding 1D, 2D NMR, IR and HRMS spectra. Compound 4 was confirmed by X-ray crystallographic analysis.

Key words: Caragana intermedia, sesquiterpenes, indane, eudesmene