有机化学 ›› 2023, Vol. 43 ›› Issue (7): 2492-2498.DOI: 10.6023/cjoc202212025 上一篇    下一篇

研究论文

O2促进下五元环烯胺的C—H亚胺化

范威*()   

  1. 滁州城市职业学院科技处 安徽滁州 239000
  • 收稿日期:2022-12-19 修回日期:2023-01-22 发布日期:2023-03-17
  • 通讯作者: 范威
  • 基金资助:
    安徽省教育厅质量工程(2020kfkc362); 滁州城市职业学院平台(2023zkzd05)

O2-Enabled C—H Imination of Five-Membered Cyclic Enamines

Wei Fan()   

  1. Science and Technology Office, Chuzhou City Vocation College, Chuzhou 239000
  • Received:2022-12-19 Revised:2023-01-22 Published:2023-03-17
  • Contact: Wei Fan
  • Supported by:
    Quality Engineering Project of Anhui Provincial Education Department(2020kfkc362); Platform Project of Chuzhou City Vocation College(2023zkzd05)

报道了一个O2促进下五元环烯胺的C—H亚胺化反应. 在微波辐射下, 季酮酸或1,3-环戊二酮衍生的烯胺酮、芳酮醛水合物和芳胺三组分参与的无金属催化反应进展顺利, 以良好的产率和完全的立体选择性得到了一系列α-烯胺基-α-芳酰基亚胺衍生物. 在该反应过程中, 空气充当绿色氧化剂, 水是唯一的副产物.

关键词: 三组分, 区域选择性亚胺化

An O2-enabled C—H imination of five-membered cyclic enamines is reported. Metal-free catalytic three- component reactions of tetronic acid- or 1,3-cyclopentanedione-derived enaminones with arylglyoxals and arylamines worked well under microwave irradiation, furnishing a series of α-enamino-α-aroyl imines with good yields and complete stereoselectivity. In this reaction process, air serves as the green oxidant with water as the sole byproduct.

Key words: three component, regioselective imination