3-芳基茚基膦配体的合成及其在低催化剂用量下Suzuki-Miyaura交叉偶联反应中的应用

doi:10.6023/cjoc202603027

研究论文

3-芳基茚基膦配体的合成及其在低催化剂用量下Suzuki-Miyaura交叉偶联反应中的应用

陈琼^b, 陈歆雨^b, 郭友利^b, 闫梦琪^b, 孟思璇^b, 陈建^b, 袁佳^*,a,b, 余广鳌^*,b

^a武汉纺织大学纺织新材料与先进加工全国重点实验室武汉 430200;
^b华中师范大学绿色农药全国重点实验室化学学院武汉 430079

收稿日期:2026-03-19 修回日期:2026-05-26
基金资助:
国家自然科学基金(No. 22371084, 21072071, 21472060, 21772058)、111计划项目(No. B17019)和华中师范大学中央高校基本科研业务费专项资金(No. CCNU17CG0011, CCNU17KYZHSY07, CCNU18KYZHSY06)资助项目.

Synthesis and application of 3-aryl substituted indenyl phosphines in Suzuki-Miyaura cross-coupling reactions at low catalyst loadings

Qiong Chen^b, Xinyu Chen^b, Youli Guo^b, Sixuan Meng^b, Jian Chen^b, Jia Yuan^a,b,*, Guang-Ao Yu^b,*

^aState Key Laboratory of New Textile Materials and Advanced Processing, Wuhan Textile University, Wuhan 430200;
^bNational Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan 430079, P.R. China

Received:2026-03-19 Revised:2026-05-26
Contact: ^*E-mail: jyuan@wtu.edu.cn; yuguang@mail.ccnu.edu.cn
Supported by:
Natural Science Foundation of China (No. 22371084, 21072071, 21472060 and 21772058), the 111 Project B17019, self-determined research funds of CCNU from the colleges’ basic research and operation of MOE (No. CCNU17CG0011, CCNU17KYZHSY07, and CCNU18KYZHSY06).

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摘要/Abstract

本文报道了一类新型的3-芳基取代茚基膦配体L1-L4,该类配体可促进钯催化的Suzuki-Miyaura交叉偶联反应,提高关键农药中间体1和2的合成效率。值得注意的是,Pd(OAc)₂的催化剂用量可低至0.02 mol%。

关键词: 茚基, 膦配体, Suzuki-Miyaura交叉偶联反应, 农药中间体

This study describes a new class of 3-substituted indenyl phosphine ligands L1-L4, which can improve the efficiency of the synthesis of the key pesticide intermediates 1 and 2 by Palladium-catalyzed Suzuki-Miyaura cross-coupling reactions. It is noted that the catalyst loading of Pd(OAc)₂ down to 0.02 mol% can be achieved.

Key words: Indenyl, Phosphine ligand, Suzuki-Miyaura cross-coupling reactions, Pesticide intermediates

引用此文

陈琼, 陈歆雨, 郭友利, 闫梦琪, 孟思璇, 陈建, 袁佳, 余广鳌. 3-芳基茚基膦配体的合成及其在低催化剂用量下Suzuki-Miyaura交叉偶联反应中的应用[J]. 有机化学, doi: 10.6023/cjoc202603027.

Qiong Chen, Xinyu Chen, Youli Guo, Sixuan Meng, Jian Chen, Jia Yuan, Guang-Ao Yu. Synthesis and application of 3-aryl substituted indenyl phosphines in Suzuki-Miyaura cross-coupling reactions at low catalyst loadings[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202603027.

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