Bioactive Natural Products of Aspergillus sp. OUCMDZ-1914, an Aciduric Fungus from the Mangrove Soils

doi:10.6023/cjoc201504007

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (9): 1955-1960.DOI: 10.6023/cjoc201504007 Previous Articles Next Articles

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红树林耐酸真菌Aspergillussp.OUCMDZ-1914次生代谢产物研究

林亚伟^a, 王立平^b, 王乂^a, 王伟^a, 郝杰杰^a, 朱伟明^a

a 中国海洋大学医药学院海洋药物教育部重点实验室青岛 266003;
b 贵州省及中国科学院天然产物化学重点实验室贵阳 550002

收稿日期:2015-04-07 修回日期:2015-05-06 发布日期:2015-05-14
通讯作者: 王乂, 朱伟明 E-mail:wangyi0213@ouc.edu.cn;weimingzhu@ouc.edu.cn
基金资助:
国家自然科学基金(Nos. 81373298 & 21172204)、高科技发展计划(Nos. 2013AA092901 & 2012AA092104)以及国家自然科学基金-山东联合资助海洋研究中心(No. U1406402)资助项目.

Bioactive Natural Products of Aspergillus sp. OUCMDZ-1914, an Aciduric Fungus from the Mangrove Soils

Lin Yawei^a, Wang Liping^b, Wang Yi^a, Wang Wei^a, Hao Jiejie^a, Zhu Weiming^a

a Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003;
b Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002

Received:2015-04-07 Revised:2015-05-06 Published:2015-05-14
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 81373298 & 21172204), the National High-Tech R&D Program of China (Nos. 2013AA092901 & 2012AA092104), and the NSFC-Shandong Joint Fund for Marine Science Research Centers (No. U1406402).

1. Bioactive Natural Products of Aspergillus sp. OUCMDZ-1914, an Aciduric Fungus from the Mangrove Soils.PDF(1471KB)

Abstract

In order to investigate bioactive metabolites from aciduric fungi, Aspergillus sp. OUCMDZ-1914 was isolated from the mangrove soil in Wenchang Hainan, China. The strain was fermented under low pH and the products were extracted and the extract was purified by column chromatography over silica gel, Sephadex LH-20 and semi-preparative HPLC. The structures were identified by means of NMR, MS, UV, IR and X-ray single crystal diffraction. As a results, a new compound, methyl (2Z,3E,5E,7E,9E)-4,10-dimethyl-11-(2,5-dioxopyrrolidin-3-yl)-2-(2-hydroxyethylidene)-11-oxoundeca-3,5,7,9-tetraenoate (1), along with eight known ones, RKB-3384A (2), JBIR-74 (3), JBIR-75 (4), secalonic acid D (5), oxaline (6), meleagrin (7), okaramine H (8) and citreorosein (9), was obtained. Compound 2 showed H1N1 influenza virus inhibition with an IC₅₀ value of 116.2 μmol/L. Compound 5 showed cytotoxicities against A549, MCF-7 and K562 cell lines with the IC₅₀ values of 0.23, 4.45 and 3.68 μmol/L respectively. Compound 6 showed α-glucosidase inhibition with an IC₅₀ value of 0.84 mmol/L.

Key words: mangrove fungi, natural products, bioactivities

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Lin Yawei, Wang Liping, Wang Yi, Wang Wei, Hao Jiejie, Zhu Weiming. Bioactive Natural Products of Aspergillus sp. OUCMDZ-1914, an Aciduric Fungus from the Mangrove Soils[J]. Chin. J. Org. Chem., 2015, 35(9): 1955-1960.

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红树林耐酸真菌Aspergillussp.OUCMDZ-1914次生代谢产物研究

Bioactive Natural Products of Aspergillus sp. OUCMDZ-1914, an Aciduric Fungus from the Mangrove Soils

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