Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (2): 327-338.DOI: 10.6023/cjoc201907047 Previous Articles     Next Articles


施展a,b, 聂克睿a, 刘畅a, 张明智a, 章维华a   

  1. a 南京农业大学理学院 南京 210095;
    b 复旦大学化学系 上海 200433
  • 收稿日期:2019-07-28 修回日期:2019-10-03 发布日期:2019-11-07
  • 通讯作者: 张明智, 章维华;
  • 基金资助:

Biological Activities of 3-(5-Oxazolyl)indole Natural Products and Advances on Synthesis of Its Derivatives

Shi Zhana,b, Nie Keruia, Liu Changa, Zhang Mingzhia, Zhang Weihuaa   

  1. a College of Sciences, Nanjing Agricutural University, Nanjing 210095;
    b Department of Chemistry, Fudan University, Shanghai 200433
  • Received:2019-07-28 Revised:2019-10-03 Published:2019-11-07
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21602110), the National Key R&D Program of China (No. 2018YFC1602804), the Jiangsu Provincial Science Foundation for Youths (No. BK20160734) and the Fundamental Research Funds for the Central Universities (Nos. KYTZ201604, KYLH201908).

3-(5-Oxazolyl)indole-type natural products such as pimprinine and streptochlorin, widely exist in marine microorganism, because of their diverse biological activity, 3-(5-oxazolyl)indoles show good research and development potential in the field of medicine and pesticide. Numerous studies have been performed to synthesize 3-(5-oxazolyl)indole-type natural products, in which the construction of indole ring and oxazole ring is the most important part. In this paper, the reported natural products with 3-(5-oxazolyl)indole skeleton structure and their biological activities are summarized, and the synthetic methods for 3-(5-oxazolyl)indole skeleton and some of their mechanism are also reviewed. The application prospect of 3-(5-oxazol-yl)indole as a dominant active structure in the future was discussed.

Key words: 3-(5-oxazolyl)indole, natural products, biological activities, synthesis, review