Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (2): 291-303.DOI: 10.6023/cjoc201708055 Previous Articles     Next Articles

Special Issue: 碳氢活化合辑2018-2019



汪珊a, 严沣a, 汪连生a, 朱磊a,b   

  1. a 湖北工程学院化学与材料科学学院 孝感 432000;
    b 生物质资源转化利用湖北省协同创新中心 孝感 432000
  • 收稿日期:2017-08-26 修回日期:2017-09-21 发布日期:2017-10-24
  • 通讯作者: 汪连生, 朱磊;
  • 基金资助:


Recent Advances in Directing Group-Induced C-H Activation Reactions

Wang Shana, Yan Fenga, Wang Lianshenga, Zhu Leia,b   

  1. a School of Chemistry and Materials Science, Hubei Engineering University, Xiaogan 432000;
    b Hubei Collaborative Innovation Center for Biomass Conversion and Utilization, Xiaogan 432000
  • Received:2017-08-26 Revised:2017-09-21 Published:2017-10-24
  • Contact: 10.6023/cjoc201708055;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21774029, 21304032) and the Natural Science Foundation of Hubei Province (Nos. 2016CFB104, 2015CFC772).

C-H bonds are widely existed in almost all the organic compounds. Transition-metal-catalyzed C-H functionalizations usually have high reaction efficiency and high atom-economy. However, traditional strategies based on such transition-metal catalyzed C-H activations generally result in poor selectivities, because C-H bonds in one molecule facilely display similar reactivity. It is difficult to be utilized in preparation of natural products, pharmaceuticals and biomolecules. However, directing group can induce the metal to activate proximal C-H bonds via cyclometallated intermediates, improve the regioselectivity of the transformations. Therefore, it is extremely significant to deveplop auxiliary-induced C-H bonds activations. The research progress of directing group-induced C-H activation reactions and mechanisms for recent ten years are sumarized.

Key words: C-H activation, regioselectivity, directing group, transition-metal