Two New Isocoumarins Isolated from a Mangrove-Derived Fungus Penicillium citrinum HL-5126

doi:10.6023/cjoc201812008

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (5): 1479-1482.DOI: 10.6023/cjoc201812008 Previous Articles Next Articles

Notes

一株红树来源真菌Penicillium citrinum HL-5126中两个新异香豆素化合物

梅荣清, 黄国雷, 王斌, 白猛, 罗由萍, 陈光英, 郑彩娟

热带药用植物化学教育部重点实验室海南省热带药用植物化学重点实验室海南师范大学化学与化工学院海口 571158

收稿日期:2018-12-05 修回日期:2018-12-29 发布日期:2019-01-18
通讯作者: 郑彩娟 E-mail:caijuan2002@163.com
基金资助:
国家自然科学基金（Nos.21462015，31760093）、海南省自然科学基金（No.218MS045）、教育部创新团队发展计划（No.IRT-16R19）资助项目.

Two New Isocoumarins Isolated from a Mangrove-Derived Fungus Penicillium citrinum HL-5126

Mei Rongqing, Huang Guolei, Wang Bin, Bai Meng, Luo Youping, Chen Guangying, Zheng Caijuan

Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158

Received:2018-12-05 Revised:2018-12-29 Published:2019-01-18
Contact: 10.6023/cjoc201812008 E-mail:caijuan2002@163.com
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21462015, 31760093), the National Natural Science Foundation of Hainan Province (No. 218MS045), the Program for Innovative Research Team in University (No. IRT-16R19).

1. Two New Isocoumarins Isolated from a Mangrove-Derived Fungus Penicillium citrinum HL-5126.PDF(710KB)

Abstract

Two new isocoumarins derivatives, penicimarins J (1) and K (2), were isolated from the mangrove-derived fungus Penicillium citrinum HL-5126. Their structures were elucidated through extensive 1D NMR, 2D NMR and HR-ESI-MS spectroscopic analyses. The absolute configurations of 1 and 2 were determined by comparison of their circular dichroism (CD) spectra with the literature. Compounds 1 and 2 showed inhibitory activities against α-glucosidase with the IC₅₀ values of 18.37 and 25.86 μg/mL, respectively.

Key words: Penicillium citrinum, isocoumarin, antibacterial activity, α-glucosidase inhibitory activity

Cite this article

Mei Rongqing, Huang Guolei, Wang Bin, Bai Meng, Luo Youping, Chen Guangying, Zheng Caijuan. Two New Isocoumarins Isolated from a Mangrove-Derived Fungus Penicillium citrinum HL-5126[J]. Chin. J. Org. Chem., 2019, 39(5): 1479-1482.

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一株红树来源真菌Penicillium citrinum HL-5126中两个新异香豆素化合物

Two New Isocoumarins Isolated from a Mangrove-Derived Fungus Penicillium citrinum HL-5126

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