Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (10): 2892-2897.DOI: 10.6023/cjoc201903049 Previous Articles     Next Articles

ARTICLES

5-(1-苯基-3-苯基丙基-2-炔基)-2,2-亚戊基-1,3-二噁烷-4,6-二酮衍生物的有效合成

范乃立a, 许招会a*(), 向正兵b, 肖强b, 廖传文b*()   

  1. a 江西师范大学化学化工学院 南昌 330027
    b 江西省人民医院外科 南昌 330006
  • 收稿日期:2019-03-24 修回日期:2019-04-30 发布日期:2019-05-28
  • 通讯作者: 许招会,廖传文 E-mail:gotoxzh@163.com;jxnclcw@163.com
  • 基金资助:
    江西省省研究生创新基金(YC2015-B023);江西省教育厅科技攻关(No. GJJ170170)

Efficent Synthesis of 5-(1-Phenyl-3-phenylprop-2-ynyl)-2,2-pentylidene-1,3-dioxane-4,6-dione Derivatives

Fan, Nailia, Xu, Zhaohuia*(), Xiang, Zhengbingb, Xiao, Qiangb, Liao, Chuanwenb*()   

  1. a Department of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330027
    b Department of General Surgery, Jiangxi Province People's Hospital, Nanchang 330006
  • Received:2019-03-24 Revised:2019-04-30 Published:2019-05-28
  • Contact: Xu, Zhaohui,Liao, Chuanwen E-mail:gotoxzh@163.com;jxnclcw@163.com
  • Supported by:
    Project supported by the Graduate Innovation Foundation of Jiangxi Province(YC2015-B023);the Science and Technology Research Project of Jiangxi Provincial Education Department(No. GJJ170170)

A convenient and efficient approach for the synthesis of 5-(1-phenyl-3-phenylprop-2-ynyl)-2,2-pentylidene-1,3- dioxane-4,6-dione derivatives through a three-component reaction of aldehydes with 2,2-pentylidene-1,3-dioxane-4,6-dione and arylacetylene in the presence of Cu(OAc)2·H2O/Cu is described with 12 examples. The reaction tolerates a wide range of aldehydes furnishing the products with good to excellent isolated yields (65%~88%). Additionally, the synthetic protocol has the advantages of wild conditions, simple operation, and excessive copper reused.

Key words: multicomponent reaction, copper acetate/copper, 2,2-pentylidene-1;3-dioxane-4;6-dione, 5-(1-phenyl-3-phe- nylprop-2-ynyl)-2;2-pentylidene-1;3-dioxane-4,6-dione derivatives