Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (2): 341-349.DOI: 10.6023/cjoc201708040 Previous Articles     Next Articles

Special Issue: 元素有机化学合辑2018-2019



刘双a, 李玉明a, 王典a, 魏榕a, 苗志伟a,b   

  1. a 南开大学化学学院 元素有机化学国家重点实验室 天津 300071;
    b 清华大学 生命有机磷化学及化学生物学教育部重点实验室 北京 100084
  • 收稿日期:2017-08-20 修回日期:2017-09-24 发布日期:2017-10-16
  • 通讯作者: 苗志伟
  • 基金资助:


Research Progress of Asymmetric Synthesis of Optically Active P-Stereogenic Organophosphoryl Compounds by Chiral Induction

Liu Shuanga, Li Yuminga, Wang Diana, Wei Ronga, Miao Zhiweia,b   

  1. a State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071;
    b Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Ministry of Education, Tsinghua University, Beijing 100084
  • Received:2017-08-20 Revised:2017-09-24 Published:2017-10-16
  • Contact: 10.6023/cjoc201708040
  • Supported by:

    Project supported by the National Key Research and Development Program of China (No. 2016YFD0201200).

Organo-phosphorus chemistry is an important branch of organic chemistry and life science research. P-Stereogenic organophosphorus compounds have attracted great interest due to their potential applications in the fields of pharmaceutical chemistry, agrochemistry, material science and as ligands for asymmetric catalysis. The preparation of enantiomerically enriched phosphorus compounds with P-stereogenic centers using natural chiral compounds as chiral auxiliary has received considerable attention. The recent development of the asymmetric synthesis of P-stereogenic organophosphoryl compounds employing menthol, sparteine, ephedrine, and carbohydrates as chiral auxiliary is summarized.

Key words: P-stereogenic organophosphorus compound, chiral induction, asymmetric synthesis