Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (3): 672-676.DOI: 10.6023/cjoc201710004 Previous Articles     Next Articles



戈敏, 张丽军, 涂兵, 周双六   

  1. 功能分子固体教育部重点实验室 分子基材料安徽省重点实验室安徽师范大学化学与材料科学学院 芜湖 241000
  • 收稿日期:2017-10-07 修回日期:2017-11-09 发布日期:2017-11-17
  • 通讯作者: 张丽军,;周双六,;
  • 基金资助:


Asymmetric Addition of 3-Thienyl Aluminum to Ketones Catalyzed by the Simple Titanium Catalytic System of (S)-1,1'-Binaphthol

Ge Min, Zhang Lijun, Tu Bing, Zhou Shuangliu   

  1. Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000
  • Received:2017-10-07 Revised:2017-11-09 Published:2017-11-17
  • Contact: 10.6023/cjoc201710004;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21372009, 21672004).

The optically active diaryl alcohols bearing thienyl group are well-known for their biological activity as well as key substructure in bioactive compounds and pharmaceuticals. The asymmetric addition of 3-thienyl aluminum to ketones afforded the optically active 3-thienyl arylethanols in good yields with high enantioselectivities of up to 91% ee employing the simple titanium catalytic system of (S)-1,1'-binaphthol. The catalytic system could also suit for various ketones bearing an electron-donating or electron-withdrawing groups to afford the corresponding diarylethanols containing substituted 3-thienyl groups.

Key words: asymmetric synthesis, thienyl, aluminum, titanium, ketones