Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (6): 1540-1548.DOI: 10.6023/cjoc202002029 Previous Articles     Next Articles

Special Issue: 有机电合成虚拟专辑


李梦帆, 王榕, 郝文娟, 姜波   

  1. 江苏师范大学化学与材料科学学院 徐州 221116
  • 收稿日期:2020-02-23 修回日期:2020-03-26 发布日期:2020-04-10
  • 通讯作者: 姜波
  • 基金资助:

Electrocatalytic Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles

Li Mengfan, Wang Rong, Hao Wenjuan, Jiang Bo   

  1. School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116
  • Received:2020-02-23 Revised:2020-03-26 Published:2020-04-10
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21971090), and the Postgraduate Research Innovation Program of Jiangsu Province (No. SJKY19_2003).

1,3,4-Oxadiazoles, standing for a class of five-membered heterocyclic compounds with multiple heteroatoms, show anti-inflammatory, anti-convulsant, anti-inositol and other biological activities. They also served as important intermediates in organic synthesis. Thus, the development of general and straightforward methods for their synthesis is of great significance. In this paper one-step synthesis of non-symmetric 2,5-disubstituted 1,3,4-oxadiazole derivatives with good yield was completed under electrocatalytic conditions by using cheap and readily available aldehydes and hydrazides as starting materials. Their structures were confirmed by IR, 1H NMR, 13C NMR and HRMS analyses. The reaction features mild conditions, high atom-economy and wide substrate scope, providing a green and sustainable synthetic protocol for constructing 1,3,4-oxadiazole skeleton.

Key words: chemistry, 1,3,4-oxadiazoles, electrosynthesis, radcial cyclization