Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (7): 1860-1873.DOI: 10.6023/cjoc202002038 Previous Articles     Next Articles


董晓娟, 金伟伟, 刘晨江   

  1. 新疆大学化学化工学院 乌鲁木齐 830046
  • 收稿日期:2020-02-26 修回日期:2020-04-10 发布日期:2020-04-23
  • 通讯作者: 金伟伟, 刘晨江;
  • 基金资助:

Recent Advances in Transition-Metal Catalyzed Defunctionalization Reaction

Dong Xiaojuan, Jin Weiwei, Liu Chenjiang   

  1. School of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046
  • Received:2020-02-26 Revised:2020-04-10 Published:2020-04-23
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21702175, 21961037) and the 1000 Youth Talents Plan.

Functional groups are atoms or groups that determine the chemical properties of organic compounds. It often plays the role of guiding group in organic synthesis chemistry. Defunctionalization is the chemical transformation of a substrate with more functional groups into a compound with fewer functional groups, which has positive applications in solving environmental problems, resource shortage and biomass degradation. But due to the bond energy, heating, acid or base are often involved in defunctionalization. In recent years, defunctionalization has been moving toward a greener and more sustainable direction. Metal catalysis provides a new way for defunctionalization. The recent applications of different metal-mediated defunctionalization in organic synthesis and their mechanism are summarized.

Key words: transition metal, defunctionalization, protonation, selectivity