Synthesis and Preliminary Exploration of Biological Activity of 3-Aryl-4-arylamine Methyl Isoxazoles

doi:10.6023/cjoc202003026

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (7): 2108-2113.DOI: 10.6023/cjoc202003026 Previous Articles Next Articles

3-芳基-4-芳胺甲基异噁唑衍生物的合成及其生物活性初探

李倩倩^a, 吴中梅^a, 张敏^a, 张一平^a, 周英楷^a, 邓红梅^c, 宋力平^a,b

a 上海大学理学院化学系上海 200444;
b 中国科学院上海有机化学研究所有机氟化学重点实验室上海 200032;
c 上海大学微结构重点实验室上海 200444

收稿日期:2020-03-10 修回日期:2020-04-09 发布日期:2020-05-08
通讯作者: 张敏, 宋力平 E-mail:mzhang@shu.edu.cn;lpsong@shu.edu.cn
基金资助:
中国科学院上海有机化学研究所有机氟化学重点实验室资助项目.

Synthesis and Preliminary Exploration of Biological Activity of 3-Aryl-4-arylamine Methyl Isoxazoles

Li Qianqian^a, Wu Zhongmei^a, Zhang Min^a, Zhang Yiping^a, Zhou Yingkai^a, Deng Hongmei^c, Song Liping^a,b

a Department of Chemistry, College of Science, Shanghai University, Shanghai 200444;
b Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032;
c Laboratory for Microstructures, Shanghai University, Shanghai 200444

Received:2020-03-10 Revised:2020-04-09 Published:2020-05-08
Supported by:
Project supported by the Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.

1. 202108S.pdf(1773KB)

Abstract

The synthesis of isoxazole derivatives has been paid much attention by organic synthetic chemists because isoxazoles usually exhibit good biological activity such as insecticidal and bactericidal activity. In this study, a series of 3-aryl-4-arylamine methyl isoxazole derivatives were synthesized from ethyl 3-arylisoxazole-4-carboxylate by reduction, bromination and substitution reaction. The synthesized compounds were identified by ¹H NMR, ¹³C NMR and HRMS, and the preliminary bioactivity test results showed that some compounds obtained had good inhibitory effects anainst aphids and armyworms.

Key words: isoxazole derivative, synthesis, arylamine methyl group, biological activity

Cite this article

Li Qianqian, Wu Zhongmei, Zhang Min, Zhang Yiping, Zhou Yingkai, Deng Hongmei, Song Liping. Synthesis and Preliminary Exploration of Biological Activity of 3-Aryl-4-arylamine Methyl Isoxazoles[J]. Chinese Journal of Organic Chemistry, 2020, 40(7): 2108-2113.

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3-芳基-4-芳胺甲基异噁唑衍生物的合成及其生物活性初探

Synthesis and Preliminary Exploration of Biological Activity of 3-Aryl-4-arylamine Methyl Isoxazoles

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