Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (11): 3536-3558.DOI: 10.6023/cjoc202010025 Previous Articles     Next Articles

Special Issue: 创刊四十周年专辑


王路宁, 余志祥   

  1. 北京大学化学与分子工程学院 北京分子科学国家研究中心 生物有机与分子工程教育部重点实验室 北京 100871
  • 收稿日期:2020-10-16 修回日期:2020-11-09 发布日期:2020-11-12
  • 通讯作者: 余志祥

Transition-Metal-Catalyzed Cycloadditions for the Synthesis of Eight-Membered Carbocycles: an Update from 2010 to 2020

Wang Lu-Ning, Yu Zhi-Xiang   

  1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871
  • Received:2020-10-16 Revised:2020-11-09 Published:2020-11-12

Eight-membered carbocycles are widely found in natural products with significant biological activities and other molecules ranging from perfumes to potential materials. Therefore, accessing these eight-membered carbocycle embedded molecules is important for drug discovery, biological investigation, fragrance industry, material development and many other fields. However, the synthesis of eight-membered carbocycles is still posing challenges to synthetic chemists. Hence, tremendous efforts have been endeavored by many leading chemists to discover and develop new reactions in order to synthesize eight-membered carbocycles. Among these reactions, transition-metal-catalyzed cycloadditions of [m+n], [m+n+o], [m+ n+o+p] have evolved as powerful tools to achieve this aim. This topic has been reviewed in 2010. Summarized here are many new developments in this field and applications of the previously developed reactions in natural product synthesis since then.

Key words: eight-membered carbocycles, transition metal catalysis, cycloaddition, total synthesis