Aggregation-Induced Emission Photosensitizers for Photodynamic Antimicrobial Therapy

doi:10.6023/cjoc202503036

Chinese Journal of Organic Chemistry ›› 2025, Vol. 45 ›› Issue (11): 3998-4012.DOI: 10.6023/cjoc202503036 Previous Articles Next Articles

REVIEWS

聚集诱导发光光敏剂用于光动力抗菌治疗

陈怡萱, 赵征^*()

香港中文大学(深圳)理工学院广东省聚集体科学基础研究卓越中心广东省聚集体科学基础研究卓越中心广东深圳 518172

收稿日期:2025-03-31 修回日期:2025-06-02 发布日期:2025-06-30
基金资助:
国家自然科学基金(52333007); 国家自然科学基金(52273197); 国家自然科学基金(62205384); 深圳市聚集体功能材料重点实验室(ZDSYS20211021111400001); 深圳市科技创新委员会(KQTD20210811090142053); 深圳市科技创新委员会(JCYJ20220818103007014); 深圳市科技创新委员会(GJHZ20210705141810031); 及广州市科技计划(2023A04J0069)

Aggregation-Induced Emission Photosensitizers for Photodynamic Antimicrobial Therapy

Yixuan Chen, Zheng Zhao^*()

Guangdong Basic Research Center of Excellence for Aggregate Science, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Shenzhen, Guangdong 518172

Received:2025-03-31 Revised:2025-06-02 Published:2025-06-30
Contact: *E-mail: zhaozheng@cuhk.edu.cn
Supported by:
National Natural Science Foundation of China(52333007); National Natural Science Foundation of China(52273197); National Natural Science Foundation of China(62205384); Shenzhen Key Laboratory of Functional Aggregate Materials(ZDSYS20211021111400001); Science Technology Innovation Commission of Shenzhen Municipality(KQTD20210811090142053); Science Technology Innovation Commission of Shenzhen Municipality(JCYJ20220818103007014); Science Technology Innovation Commission of Shenzhen Municipality(GJHZ20210705141810031); Science and Technology Program of Guangzhou City(2023A04J0069)

Bacterial resistance poses a considerable threat to human health. The research of new antibacterial materials is very important for enhancing human health, developing new therapies and solving the problem of antibiotic resistance. Photo- dynamic therapy has the characteristics of precise treatment, high selectivity, non-invasiveness, low toxicity, few side effects, and wide application range, which has been widely concerned in the field of antibacterial therapy. The aggregation-induced emission (AIE) materials can overcome the concentration quenching effect (ACQ) caused by aggregation in traditional materials, thereby becoming an excellent antibacterial material with excellent photostability and reactive oxygen generation ability. The molecular structure, bactericidal strategies, and therapeutic applications of AIE photodynamic materials are introduced, and the future development trend of AIE photodynamic materials is prospected, which can help readers quickly understand the latest research progress of AIE photosensitizers in wound repair and treatment of drug resistant bacterial infections, and provide ideas for the development of new antibacterial materials.

Key words: aggregation-induced emission (AIE), antimicrobial therapy, photodynamic therapy, antimicrobial resistance

Cite this article

Yixuan Chen, Zheng Zhao. Aggregation-Induced Emission Photosensitizers for Photodynamic Antimicrobial Therapy[J]. Chinese Journal of Organic Chemistry, 2025, 45(11): 3998-4012.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

share this article

Fig. & Tab. 14

Figure 1. (a) Non-emissive behavior of tetraphenylethene (TPE) in solution and its emissive behavior upon aggregation due to the restriction of intramolecular rotations (RIR) and (b) AIE activity of cyclooctatetrathiophene (COTh) in the aggregate-state due to the restriction of intramolecular vibration (RIV) Reproduced with permission.[17]

Figure 2. Jablonski diagram

Figure 3. (a) Molecular structure of TTVP and (b) its photodynamic properties[27]; (c) Molecular structure of TBP-1 and TBP-2 and (d) their photodynamic properties[29]; (e) Molecular structure of PIO-PyBu; (f) Static water contact angles on the drop-casted films of PIO-PyBu, and (g) SEM images of kiln-dried films from the aqueous solution/suspension [10 μmol/L, with 1% dimethyl sulfoxide (DMSO)] of PIO-PyBu[32]

Figure 4. (a) Molecular structure of Ir1; (b) Structure of Gram-Positive Bacteria Containing LTA and Gram-Negative Bacteria Containing LPS; (c) Effect of Ir1 on G(＋) bacterial membrane[46]; (d) Schematic illustration of TPIMS-8 nanoparticle photodynamic effect; (e) Plots of A/A0 versus irradiation time for the 1O2 generation of TPIM-8 (10 μmol/L) and RB (10 μmol/L) in phosphate buffered solution (PBS) with 1% DMSO using ABDA as indicator under white light irradiation (60 mW• cm－2)[47]

Figure 5. (a) Synthetic route for the zwitterionic polyurethane; (b) Zeta potentials of nanomicelles at pH=7.4 and pH=5.4[51]; (c) Processing strategy and skin wound repair mechanism of AIE/FW[52]; (d) Schematic diagram of the preparation of CS-2I@ge; (e) Plots of the absorbance of 1,3-diphenylisobenzofuran (DPBF) at 425 nm versus irradiation time in the presence of CS-2I[53] (10 μmol/L, 𝜆ex=660 nm, 10 mW•cm−2)

Figure 6. (a) Chemical structure and schematic illustration on antibacterial treatment of BDTP, (b) antibacterial activity study of BDTP against V. vulnificus with light irradiation (15 mW•cm－2, 30 min); (c) Wound healing rate after infection[58]; (d) Chemical structure of TTD and its antibacterial photodynamic therapy (APDT) processs; (e) Macrophages incubated with TTDm NPs for 12 h and then incubated with LysoTracker for 30 min; (f) Antibacterial activity of TLMs compared to TTD NPs and saline in the S. aureus infected mice under white light irradiation (400~780 nm, 300 mW•cm－2) for 10 min[60]

Figure 7. (a) Schematic showing the proposed photo-induced redox imbalance in anaerobic bacteria; (b) Photograph of a BHI agar plate containing sheep blood and biocidal activity of P. gingivalis and F. nucleatum with TBSMSPy＋ treatment under irradiation and without irradiation; (c) Schematic illustration of periodontitis modeling and treatment[63]

Figure 8. (a) Schematic illustration of the bacteriophage nanobioconjugate (MS2-DNA-AIEgen); (b) Confocal images of RAW264.7 macrophages after infected by host E. coli-15597 (stained by blue-colored DAPI) and treatment by MS2-DNA-AIEgen (red-colored emission), sequentially (the arrows indicate the overlapped bacteria and nanoconjugates that showed a purple color); (c) Cell viability tests of RAW264.7 infected by host E. coli-15597[65] (2.0×106 CFU•mL−1)

Figure 9. (a) Chemical structure of MXF-R; (b) Analysis of hydrophilic and hydrophobic parts of MXF-R and schematic diagram of MXF-R’s distribution in the lipid membrane; (c) Killing effects of MXF-R against C. albicans with or without white light irradiation (90 mW•cm－2) for 30 min[67]

Figure 10. (a) Schematic diagram of PIDT-TBT nanoparticles; (b) Infrared (IR) thermal images of PIDT-TBT NPs at different concentrations; (c) Photographs of E. faecalis, S. aureus, and S. mutans treated with PIDT-TBT NPs under 808 nm laser irradiation (1 W•cm−2) for 5 min; (d) Switched energy dissipation pathways of the AIE phototheranostic agent in the aggregated and dispersed states; (e) Bactericidal mechanism of AIE@PCM NPs against MRSA[72]

Figure 11. (a) Chemical structure of TriPE-NT; (b) Fluorescent images of E. coli and S. epidermidis incubated with 10×10－6 mol/L of TriPE-NT (orange); (c) Photographs of wounds treated by TriPE-NT plus white-light irradiation (4 mW•cm−2) after injury for different time periods;[74] (d) Schematic illustration of the preparing process of Ac-700-RF; (e) Agar plates of S. aureus and E. coli treated with Ac-700-RF with/without WL (24 mW•cm－2, 10 min) (S. aureus: Ac-700-RF 4 µg•mL−1; E. coli: Ac-700-RF 16.0 µg•mL－1)[75]

Figure 12. Schematic illustration of (a) structural characteristics of TBTCP-PMB and (b) its interactions with phages, and (c) images of LB agar plates employed for the viability quantification of E. coli[76]

Figure 13. (a) Schematic illustration of the preparation of TTVB@NM through electrospinning for microbe interception and microbial inactivation under sunlight;[81] (b) SEM images of different microbes intercepted on the surface of TTVB@NM; (c) Top-down assembly process of AIE/FW; (d) Photographs of S. aureus colonies incubated from S. aureus aerosols intercepted by HSWS and AIE/HSWS, respectively, upon irradiation with white light (16 mW•cm－2) for 10 min[82]

Figure 14. (a) Chemical structure of TTD and antibacterial photodynamic therapy (APDT) processs;[84] (b) H&E staining images of the infected skin slices subjected to different treatments

References 67

[1]	Lee, M.; Yu, E.; Chau, J.; Lam, J.; Kwok, R.; Tang, B. Z. Adv. Mater. 2024, 37, 2407707. doi: 10.1002/adma.v37.23
[2]	Wang, Y.; Yang, Y.; Shi, Y.; Song, H.; Yu, C. Adv. Mater. 2020, 32, 1904106. doi: 10.1002/adma.v32.18
[3]	Liu, Y.; Shi, L.; Su, L.; van der Mei, H. C.; Jutte, P. C.; Ren, Y.; Busscher, H. J. Chem. Soc. Rev. 2019, 48, 428. doi: 10.1039/C7CS00807D
[4]	Hussain, S.; Joo, J.; Kang, J.; Kim, B.; Braun, G. B.; She, Z.-G.; Kim, D.; Mann, A. P.; Mölder, T.; Teesalu, T.; Carnazza, S.; Guglielmino, S.; Sailor, M. J.; Ruoslahti, E. Hussain, S.; Joo, J.; Kang, J.; Kim, B.; Braun, G. B.; She, Z.-G.; Kim, D.; Mann, A. P.; Mölder, T.; Teesalu, T.; Carnazza, S.; Guglielmino, S.; Sailor, M. J.; Ruoslahti, E. Nat. Biomed. Eng. 2018, 2, 95. doi: 10.1038/s41551-017-0187-5 pmid: 29955439
[68]	Huang, L.; Cai, M.; Qiao, Q.; Li, T.; Chen, J.; Jiang, X. Carbohydr. Polym. 2023, 319, 121186. doi: 10.1016/j.carbpol.2023.121186
[69]	Feng, G.; Yuan, Y.; Fang, H.; Zhang, R.; Xing, B.; Zhang, G.; Zhang, D.; Liu, B. Chem. Commun. 2015, 51, 12490. doi: 10.1039/C5CC03807C
[70]	(a) Sun, Z.; Xiao, M.; Lv, S.; Wang, C.; Fu, H.; Tian, L.; Shi, L.; Zhu, C. Adv. Funct. Mater 2024, 2418711.
	(b) Kim, H.; Lee, Y. R.; Jeong, H.; Lee, J.; Wu, X.; Li, H.; Yoon, J. Smart Mol. 2023, 1, e20220010.
[71]	Zhou, Y.; Li, D.; Yue, X.; Shi, Y.; Li, C.; Wang, Y.; Chen, Y.; Liu, Q. Ding, D. Wang, D. Shen, J.; Adv. Healthcare Mater. 2024, 13, 2401434. doi: 10.1002/adhm.v13.30
[72]	Wang, C.; Lv, S.; Sun, Z.; Xiao, M.; Fu, H.; Tian, L.; Zhao, X.; Shi, L.; Zhu, C. Aggregate 2024, 5, e587.
[5]	Shukla, R.; Lavore, F.; Maity, S.; Derks, M. G. N.; Jones, C. R.; Vermeulen, B. J. A.; Melcrová, A.; Morris, M. A.; Becker, L. M.; Wang, X.; Kumar, R.; Medeiros-Silva, J.; Beekveld, R. A. M.; Bonvin, A. M. J. J.; Lorent, J. H.; Lelli, M.; Nowick, J. S.; MacGillavry, H. D.; Peoples, A. J.; Spoering, A. L.; Ling, L. L.; Hughes, D. E.; Roos, W. H.; Breukink, E.; Lewis, K.; Weingarth, M. Nature 2022, 608, 390. doi: 10.1038/s41586-022-05019-y
[6]	(a) Carrel, M.; Perencevich, E. N.; David, M. Z. Emerging Infect. Dis. 2015, 21, 1973. doi: 10.3201/eid2111.150452
	(b) Murray, C. J.; Ikuta, K. S.; Sharara, F.; Swetschinski, L.; Robles Aguilar, G.; Gray, A.; Han, C.; Bisignano, C.; Rao, P.; Wool, E.; Johnson, S. C.; Browne, A. J.; Chipeta, M. G.; Fell, F.; Hackett, S.; Haines-Woodhouse, G.; Kashef, B. H.; Kumaran, E. A. P.; McManigal, B.; Achalapong, S.; Agarwal, R.; Akech, S.; Albertson, S.; Amuasi, J.; Andrews, J.; Aravkin, A.; Ashley, E.; Babin, F.-X.; Bailey, F.; Baker, S.; Basnyat, B.; Bekker, A.; Bender, R.; Berkley, J. A.; Bethou, A.; Bielicki, J.; Boonkasidecha, S.; Bukosia, J.; Carvalheiro, C.; Castañeda-Orjuela, C. A.; Chansamouth, V.; Chaurasia, S.; Chiurchiù, S.; Chowdhury, F.; Clotaire Donatien, R.; Cook, A. J.; Cooper, B.; Cressey, T. R.; Criollo-Mora, E.; Cunningham, M.; Darboe, S.; Day, N. P. J.; De Luca, M.; Dokova, K.; Dramowski, A.; Dunachie, S. J.; Duong Bich, T.; Eckmanns, T.; Eibach, D.; Emami, A.; Feasey, N.; Fisher-Pearson, N.; Forrest, K.; Garcia, C.; Garrett, D.; Gastmeier, P.; Giref, A. Z.; Greer, R. C.; Gupta, V.; Haller, S.; Haselbeck, A.; Hay, S. I.; Holm, M.; Hopkins, S.; Hsia, Y.; Iregbu, K. C.; Jacobs, J.; Jarovsky, D.; Javanmardi, F.; Jenney, A. W. J.; Khorana, M.; Khusuwan, S.; Kissoon, N.; Kobeissi, E.; Kostyanev, T.; Krapp, F.; Krumkamp, R.; Kumar, A.; Kyu, H. H.; Lim, C.; Lim, K.; Limmathurotsakul, D.; Loftus, M. J.; Lunn, M.; Ma, J.; Manoharan, A.; Marks, F.; May, J.; Mayxay, M.; Mturi, N.; Munera-Huertas, T.; Musicha, P.; Musila, L. A.; Mussi-Pinhata, M. M.; Naidu, R. N.; Nakamura, T.; Nanavati, R.; Nangia, S.; Newton, P.; Ngoun, C.; Novotney, A.; Nwakanma, D.; Obiero, C. W.; Ochoa, T. J.; Olivas-Martinez, A.; Olliaro, P.; Ooko, E.; Ortiz-Brizuela, E.; Ounchanum, P.; Pak, G. D.; Paredes, J. L.; Peleg, A. Y.; Perrone, C.; Phe, T.; Phommasone, K.; Plakkal, N.; Ponce-de-Leon, A.; Raad, M.; Ramdin, T.; Rattanavong, S.; Riddell, A.; Roberts, T.; Robotham, J. V.; Roca, A.; Rosenthal, V. D.; Rudd, K. E.; Russell, N.; Sader, H. S.; Saengchan, W.; Schnall, J.; Scott, J. A. G.; Seekaew, S.; Sharland, M.; Shivamallappa, M.; Sifuentes-Osornio, J.; Simpson, A. J.; Steenkeste, N.; Stewardson, A. J.; Stoeva, T.; Tasak, N.; Thaiprakong, A.; Thwaites, G.; Tigoi, C.; Turner, C.; Turner, P.; van Doorn, H. R.; Velaphi, S.; Vongpradith, A.; Vongsouvath, M.; Vu, H.; Walsh, T.; Walson, J. L.; Waner, S.; Wangrangsimakul, T.; Wannapinij, P.; Wozniak, T.; Yu, K. C.; Zheng, P.; Sartorius, B.; Lopez, A. D.; Stergachis, A.; Moore, C.; Dolecek, C.; Naghavi, M. Young Sharma, T. E. M. W.; Lancet 2022, 399, 629. doi: 10.1016/S0140-6736(21)02724-0
[7]	Nguyen, V.-N.; Zhao, Z. B.; Tang, Z.; Yoon, J. Chem. Soc. Rev. 2022, 51, 3324. doi: 10.1039/D1CS00647A
[8]	Chen, H.; Qiu, Y.; Ding, D.; Lin, H.; Sun, W.; Wang, G. D.; Huang, W.; Zhang, W.; Lee, D.; Liu, G.; Xie, J.; Chen, X. Adv. Mater. 2018, 30, 1802748. doi: 10.1002/adma.v30.36
[73]	Zheng, Y.; Liu, W.; Chen, Y.; Li, C.; Jiang, H.; Wang, X. J. Colloid Interface Sci. 2019, 546, 1. doi: 10.1016/j.jcis.2019.03.052
[74]	Li, Y.; Zhao, Z.; Zhang, J.; Kwok, R.; Xie, S.; Tang, R.; Jia, Y.; Yang, J.; Wang, L.; Lam, J.; Zheng, W.; Jiang, X.; Tang, B. Adv. Funct. Mater. 2018, 28, 1804632. doi: 10.1002/adfm.v28.42
[75]	Yan, S.; Sun, P.; Niu, N.; Zhang, Z.; Xu, W.; Zhao, S.; Wang, L.; Wang, D.; Tang, B. Z. Adv. Funct. Mater. 2022, 32, 2200503. doi: 10.1002/adfm.v32.23
[76]	Wu, M.; Chen, L.; Chen, Q.; Hu, R.; Xu, X.; Wang, Y.; Li, J.; Feng, S.; Dong, C.; Zhang, X.; Li, Z.; Wang, L.; Chen, S.; Gu, M. Adv. Mater. 2023, 35, 2208578. doi: 10.1002/adma.v35.6
[77]	Huang, L.; Xu, S.; Wang, Z.; Xue, K.; Su, J.; Song, Y.; Chen, S.; Zhu, C.; Tang, B.; Ye, R. ACS Nano 2020, 14, 12045. doi: 10.1021/acsnano.0c05330
[78]	Sessa, L.; Diana, R.; Gentile, F.; Mazzaglia, F.; Panunzi, B. Sci. Rep. 2023, 13, 15790. doi: 10.1038/s41598-023-41315-x
[79]	Ma, K.; Zhe, T.; Li, F.; Zhang, Y.; Yu, M.; Li, R.; Wang, L. Food Hydrocoll. 2022, 123, 107147. doi: 10.1016/j.foodhyd.2021.107147
[80]	An, X.; Liu, Y.; Sun, Y.; Zhang, X.; Liu, Y.; Tao, Y.; Guo, L.; Jiang, X.; Gao, M. Chem. Eng. J. 2024, 487, 150675. doi: 10.1016/j.cej.2024.150675
[81]	Li, M.; Wen, H.; Li, H.; Yan, Z.; Li, Y.; Wang, L.; Wang, D.; Tang, B. Z. Biomaterials 2021, 276, 121007. doi: 10.1016/j.biomaterials.2021.121007
[82]	Huang, S.; Wang, Z.; Lu, X.; Gong, J.; Cheng, L.; Wang, J.; Zhang, J.; Alam, P.; Lv, Z.; Zhang, H.; Li, Y.; Qiu, Z.; Zhao, Z.; Tang, B. Z. ACS Mater. Lett. 2024, 6, 4379.
[9]	He, X.; Xiong, L.; Zhao, Z.; Wang, Z.; Luo, L.; Lan, J.; Kwok, R.; Tang, B. Z. Theranostics 2019, 9, 3223. doi: 10.7150/thno.31844
[10]	(a) Xu, F.; Zhang, G.; Zhang, K.; Chen, P.; Wang, Q.; Pan, Y.; Tang, B. Z.; Feng, H. Aggregate 2025, 6, e699.
	(b) Chen, S.; Xie, J.; Weng, S.; Meng, W.; Zheng, J.; Huang, B.; Zhan, R.; Zhang, W.; Tian, J. Chem. Eng. J. 2024, 496, 153951 doi: 10.1016/j.cej.2024.153951
[11]	(a) Zhou, S.; Tian, H.; Yan, J.; Zhang, Z.; Wang, G. Yu, X.; Sang, W.; Li, B.; Mok, G. S. P.; Song, J.; Dai, Y. Chin. Chem. Lett. 2024, 35, 108312. doi: 10.1016/j.cclet.2023.108312
	(b) Cao, J.; Zhang, T.; Chen, X.; Ma, X.; Fan, J. Smart Mol. 2025, 3, e20240023.
[12]	Wan, Y.; Fu, L. H.; Li, C.; Lin, J.; Huang, P. Adv. Mater. 2021, 33, 2103978. doi: 10.1002/adma.v33.48
[13]	Liu, Y.; Xu, S.; Lyu, Q.; Huang, Y.; Wang, W. Aggregate 2024, 5, e443.
[14]	Luo, J.; Xie, Z.; Lam, J. W. Y.; Cheng, L.; Tang, B. Z.; Chen, H.; Qiu, C.; Kwok, H. S.; Zhan, X.; Liu, Y.; Zhu, D. Chem. Commun. 2001, 1740.
[15]	Zhao, Z.; Zhang, H.; Lam, J. W. Y.; Tang, B. Z. Angew. Chem., Int. Ed. 2020, 59, 9888. doi: 10.1002/anie.v59.25
[16]	Mei, J.; Leung, N. L. C.; Kwok, R. T. K.; Lam, J. W. Y.; Tang, B. Z. Chem. Rev. 2015, 115, 11718. doi: 10.1021/acs.chemrev.5b00263 pmid: 26492387
[17]	Zhao, Z.; Zheng, X.; Du, L.; Xiong, Y.; He, W.; Gao, X.; Li, C.; Liu, Y.; Xu, B.; Zhang, J.; Song, F.; Yu, Y.; Zhao, X.; Cai, Y.; He, X.; Kwok, R. T. K.; Lam, J. W. Y.; Huang, X.; Phillips, D. L.; Wang, H.; Tang, B. Z. Nat. Commun. 2019, 10, 2952. doi: 10.1038/s41467-019-10818-5 pmid: 31273202
[18]	(a) Wan, Q.; Zhang, R.; Zhuang, Z.; Li, Y.; Huang, Y.; Wang, Z.; Zhang, W.; Hou, J.; Tang, B. Z. Adv. Funct. Mater. 2020, 30, 2002057. doi: 10.1002/adfm.v30.39
	(b) Zhang, Z.; Deng, Z.; Zhu, L.; Zeng, J.; Cai, X.; Qiu, Z.; Zhao, Z.; Tang, B. Z. Regener. Biomater. 2023, 10, rbad044.
[19]	(a) Tang, Y.; Xie, Y.; Bai, X.; Zhao, C.; Zheng, Y.; Liang, H.; Ma, Z.; Wang, Z.; Wan, Q. Chem.-Asian J. 2025, 20, e202401060.
	(b) He, C.; Feng, P.; Hao, M.; Tang, Y.; Wu, X.; Cui, W.; Ma, J.; Ke, C. Adv. Funct. Mater. 2024, 34, 2402588. doi: 10.1002/adfm.v34.38
	(c) Sun, Z.; Wang, J.; Xiao, M.; Wu, K.; Wang, C.; Fu, H.; Lv, S.; Shi, L.; Zhu, C. Chem. Eng. J. 2024, 499. 155782.
[20]	(a) Xie, S.; Manuguri, S.; Proietti, G.; Romson, J.; Fu, Y.; Inge, A.; Wu, B.; Zhang, Y.; Häll, D.; Ramström, O.; Yan, M. Proc. Natl. Acad. Sci. U. S. A. 2017, 114, 8464. doi: 10.1073/pnas.1708556114
	(b) Ma, H.; Ma, Y.; Lei, L.; Yin, W.; Yang, Y.; Wang, T.; Yin, P.; Lei, Z.; Yang, M.; Qin, Y.; Zhang, S. ACS Sustainable Chem. Eng. 2018, 6, 15064. doi: 10.1021/acssuschemeng.8b03540
	(c) Yu, F.; Zhong, Y.; Zhang, B.; Zhou, Y.; He, M.; Yang, Y.; Wang, Q.; Yang, X.; Ren, X.; Qian, J.; Zhang, H.; Tian, M. A. Small 2024, 20, 2308071. doi: 10.1002/smll.v20.28
[21]	Zhang, L.; Jiao, L.; Zhong, J.; Guan, W.; Lu, C. Mater. Chem. Front. 2017, 1, 1829. doi: 10.1039/C7QM00125H
[22]	Zehra, N.; Dutta, D.; Malik, A.; Ghosh, S.; Iyer, P. ACS Appl. Mater. Interfaces 2018, 10, 27603. doi: 10.1021/acsami.8b07516
[23]	Cai, W.; Shen, T.; Wang, D.; Li, T.; Yu, J.; Peng, C.; Tang, B. Z. Front. Chem. 2023 10, 1088935. doi: 10.3389/fchem.2022.1088935
[24]	Kang, M.; Zhou, C.; Wu, S.; Yu, B.; Zhang, Z.; Song, N.; Lee, M.; Xu, W.; Xu, F.; Wang, D.; Wang, L.; Tang, B. Z. J. Am. Chem. Soc. 2019, 141, 16781. doi: 10.1021/jacs.9b07162
[25]	Liu, X.; Yang, Z.; Xu, W.; Chu, Y.; Yang, J.; Yan, Y.; Hu, Y.; Wang, Y.; Hua, J.; J. Mater. Chem. C 2019, 7, 12509. doi: 10.1039/C9TC04427B
[26]	Yuan, G.; Lv, C.; Liang, J.; Zhong, X.; Li, Y.; He, J.; Zhao, A.; Li, L.; Shao, Y.; Zhang, X.; Wang, S.; Cheng, Y.; He, H. Adv. Funct. Mater. 2021, 31, 2104026. doi: 10.1002/adfm.v31.36
[27]	(a) Lee, M.; Xu, W.; Zheng, L.; Yu, B.; Leung, A.; Kwok, R.; Lam, J.; Xu, F.; Wang, D.; Tang, B. Biomaterials 2020, 230, 119582. doi: 10.1016/j.biomaterials.2019.119582
	(b) Lee, M.; Yan, D.; Chau, J.; Park, H.; Ma, C.; Kwok, R.; Lam, J.; Wang, D.; Tang, B. Biomaterials 2020, 261, 120340. doi: 10.1016/j.biomaterials.2020.120340
[28]	Lee, M.; Yu, E.; Yan, D.; Chau, J.; Wu, Q.; Lam, J.; Ding, D.; Kwok, R.; Wang, D.; Tang, B. ACS Nano 2023, 17, 17004. doi: 10.1021/acsnano.3c04266
[29]	Shi, X.; Sung, Simon, H. P.; Chau, J. H. C.; Li, Y.; Liu, Z.; Kwok, R. T. K.; Liu, J.; Xiao, P.; Zhang, J.; Liu, B.; Lam, J. W. Y.; Tang, B. Z. Small Methods 2020, 4, 2000046. doi: 10.1002/smtd.v4.7
[30]	(a) Wang, J.; Xia, F.; Wang, Y.; Shi, H.; Wang, L.; Zhao, Y.; Song, J.; Wu, M.; Feng, S. ACS Appl. Mater. Interfaces 2023, 15, 17433. doi: 10.1021/acsami.2c18835
	(b) Kong, L.; He, W.; Gong, J.; Qiu, Z.; Zhao, Z.; Tang, B. Z. Aggregate 2024, 5, e597.
[31]	(a) Wang, J.; Li, J.; Shen, Z.; Wang, D.; Tang, B. ACS Nano 2023, 17, 4239. doi: 10.1021/acsnano.2c05821
	(b) Deng, Z.; Zhang, R.; Gong, J.; Zhang, Z.; Zhang, L.; Qiu, Z.; Alam, P.; Zhang, J.; Liu, Y.; Li, Y.; Zhao, Z.; Tang, B. JACS Au 2025, 5, 675. doi: 10.1021/jacsau.4c00915
[32]	Zhuang, Z.; Meng, Z.; Li, J.; Shen, P.; Dai, J.; Lou, Xi.; Xia, F.; Tang, B. Z.; Zhao, Z. ACS Nano 2022, 16, 11912. doi: 10.1021/acsnano.2c01721 pmid: 35917549
[33]	McKenzie, L. K.; Bryant, H. E.; Weinstein, J. A. Coord. Chem. Rev. 2019, 379, 2. doi: 10.1016/j.ccr.2018.03.020
[34]	Vanucci-Bacqué, C.; Wolff, M.; Delavaux-Nicot, B.; Abdallah, A.; Mallet-Ladeira, S.; Serpentini, C.; Bedos-Belval, F.; Fong, K.; Ng, X.; Low, M.; Benoist, E.; Fery-Forgues, S. Dalton Trans. 2024, 53. 11276.
[35]	Umesh; Chandran, V.; Saha, P.; Nath, D.; Bera, S.; Bhattacharya, S.; Pal, A. Nanoscale 2024, 16, 13050. doi: 10.1039/D4NR01011F
[36]	Mala, R.; Divya, D.; Vijayan, P.; Narayanasamy, M.; Thennarasu, S. ChemistrySelect 2022, 7, e202103408.
[37]	Zhang, Q.; Lu, X.; Cao, H.; Wang, H.; Zhu, T.; Tian, X.; Li, D.; Zhou, H.; Wu, J.; Tian, Y. ACS Appl. Bio Mater. 2020, 3, 8105. doi: 10.1021/acsabm.0c01206
[83]	Liu, S.; Feng, G.; Tang, B.; Liu, B. Chem. Sci. 2021, 12, 6488. doi: 10.1039/D1SC00045D
[84]	Mao, D.; Hu, F.; Kenry; Qi, G.; Ji, S.; Wu, W.; Kong, D.; Liu, B.Mater. Horiz. 2020, 7, 1138.
[85]	Yang, L.; Xiong, L.-H.; He, X. Chem. Biomed. Imaging 2025, 3, 499. doi: 10.1021/cbmi.5c00016
[38]	Li, Q.; Shao, M.; Ran, W.; Sun, X.; Liu, H.; Wang, Q.; Liu, X.; Tian, L.; Chen, G.; Liu, Z. Dyes Pigm. 2022, 201, 110231. doi: 10.1016/j.dyepig.2022.110231
[39]	Yang, X.; Yan, K.; Yang, C.; Wang, D. Chem. Eng. J. 2023, 478, 147402. doi: 10.1016/j.cej.2023.147402
[40]	Gupta, A.; Prasad, P.; Gupta, S.; Sasmal, P. ACS Appl. Mater. Interfaces 2020, 12, 35967. doi: 10.1021/acsami.0c11161
[41]	Gautam, A.; Sasmal, P. Inorg. Chem. 2025, 64, 2905. doi: 10.1021/acs.inorgchem.4c05064
[42]	Gautam, A.; Gupta, A.; Prasad, P.; Sasmal, P. K. Chem.-Asian J. 2025, 20, e202401060.
[43]	(a) Zhu, H.; Wang, S.; Wang, Y.; Song, C.; Yao, Q.; Yuan, X.; Xie, J. Biomaterials 2022, 288, 121695. doi: 10.1016/j.biomaterials.2022.121695
	(b) He, Q.; Jiang, Z.; Jiang, H.; Han, S.; Yang, G.; Yuan, X.; Zhu, H. Nanoscale 2024, 16, 14310. doi: 10.1039/D4NR01769B
	(c) Deng, S.; Peng, Z.; Zhou, F.; Zhong, G.; Cai, Z.; Tang, X.; Xu, C.; Zheng, L.; Tang, B. Z.; Zhang, J. Aggregate 2024, 5, e575.
[44]	Liu, N.; Wang, Y.; Wang, Z.; He, Q.; Liu, Y.; Dou, X.; Yin, Z.; Li, Y.; Zhu, H.; Yuan, X. Nanoscale 2022, 14, 8183. doi: 10.1039/D2NR01550A
[45]	(a) Wang, Y.; Zuo, Z.; Wang, Z.; Wu, Y.; Linghu, J.; Liu, Y.; Zhu, H.; Dou, X.; Feng, T.; Yuan, X. Chem. Eng. J. 2024, 492, 152216. doi: 10.1016/j.cej.2024.152216 pmid: 39902652
	(b) Jiang, Z.; Wei, Y.; Wang, Y.; Han, S.; Li, Z.; Liu, S.; Wang, Z.; Li, Z.; Feng, T.; Zhu, H.; Yuan, X. Nanoscale 2025, 17, 5778. doi: 10.1039/d4nr04718d pmid: 39902652
[46]	Xu, L.; Deng, P. Song, W.; Liu, M.; Wang, M.; Yu, Y.; Wang, F. ACS Mater. Lett. 2023, 5, 162.
[47]	Liu, X.; Ren, Y.; Fan, D.; Huang, S.; Ma, Y.; Ding, J.; Luo, Z.; Chen, F.; Zeng, W. Adv. Funct. Mater. 2023, 33, 2304974. doi: 10.1002/adfm.v33.45
[48]	(a) Lv, J.; Wang, S.; Qi, C.; Li, M.; Sun, Y.; Yang, Y.; Zeng, C.; Shen, R.; Ma, H. J. Mater. Chem. B 2023, 11, 9237. doi: 10.1039/D3TB01240A
	(b) Zhang, G.; Fu, X.; Zhou, D.; Hu, R.; Qin, A.; Tang, B. Z. Smart Mol. 2023, 1, e20220008.
[49]	(a) Chen, Y.; Xu, Z.; Wang, X.; Sun, X.; Xu, X.; Li, X.; Cheng, G. ACS Biomater. Sci. Eng. 2024, 10, 3401. doi: 10.1021/acsbiomaterials.4c00056 pmid: 39423317
	(b) Liu, C.; Du, W.; Jiang, L.; Li, Y.; Liu, C.; Jian, X. Polym. Eng. Sci. 2023, 63, 2596. doi: 10.1002/pen.v63.8 pmid: 39423317
	(c) Niu, N.; Yang, N.; Yu, C.; Wang, D.; Tang, B. ACS Mater. Lett. 2022, 4, 692. pmid: 39423317
	(d) Xie, Y.; Zhang, Y.; Liu, X.; Ma, X.; Qin, X.; Jia, S.; Zhong, C. Chem. Eng. J. 2021, 413. 127542. pmid: 39423317
	(e) Khattak, S.; Ullah, I.; Sohail, M.; Akbar, M. U.; Rauf, M. A.; Ullah, S.; Shen, J.; Xu, H.-T. Aggregate 2025, 6, e688. pmid: 39423317
	(f) Zhou, K.; Yu, Y.; Xu, L.; Wang, S.; Li, Z.; Liu, Y.; Kwok, R. T. K.; Sun, J.; Lam, J. W. Y.; He, G.; Zhao, Z.; Tang, B. Z. ACS Nano 2024, 18, 29930. doi: 10.1021/acsnano.4c10452 pmid: 39423317
[50]	Wang, Y.; Zhao, J.; Dong, Z.; Wang, C.; Meng, H.; Li, Y.; Jin, H. Mater. Today Chem. 2021, 21, 100537
[51]	Ren, B.; Li, K.; Liu, Z.; Liu, G.; Wang, H. J. Mater. Chem. B 2020, 8, 10754. doi: 10.1039/D0TB02272A
[52]	Huang, S.; Wang, Z.; Wu, Q.; Wu, B.; Chen, B.; Li, Y.; Qiu, Z.; Zhao, Z.; Tang, B. Z. Adv. Funct. Mater. 2025, 35, 2423123. doi: 10.1002/adfm.v35.26
[53]	Zeng, S.; Wang, Z.; Chen, C.; Liu, X.; Wang, Y.; Chen, Q.; Wang, J.; Li, H. Peng, X.; Yoon, J. Adv. Healthcare Mater. 2022, 11, 2200837. doi: 10.1002/adhm.v11.17
[54]	Poli, V., Gioia, M.; Sola-Visner, M.; Granucci, F.; Frelinger, A. L.; Michelson, A. D.; Zanoni, I. Immunity 2022, 55, 224. doi: 10.1016/j.immuni.2021.12.002
[55]	Flenker, K. S.; Burghardt, E. L.; Dutta, N.; Burns, W. J.; Grover, J. M.; Kenkel, E. J.; Weaver, T. M.; Mills, J.; Kim, H.; Huang, L.; Owczarzy, R.; Musselman, C. A.; Behlke, M. A.; Ford, B.; McNamara, J. O. Mol. Ther. 2017, 25, 1353. doi: S1525-0016(17)30113-2 pmid: 28391960
[56]	Li, Q.; Li, Y.; Min, T.; Gong, J.; Du, L.; Phillips, D.; Liu, J.; Lam, J.; Sung, H.; Williams, I.; Kwok, R.; Ho, C.; Li, K.; Wang, J.; Tang, B. Z. Angew. Chem., Int. Ed. 2020, 59, 9470. doi: 10.1002/anie.v59.24
[57]	(a) Wu, B.; Hu, K. F. Interdiscip. Med. 2024, 2, e20230038.
	(b) Ma, Y.; Qin, C.; Lei, Y.; Yang, X.; Lei, Z. Smart Mol. 2024, 2, e20240029.
	(c) Ye, Z. He, W.; Zhang, Z.; Qiu, Z.; Zhao, Z.; Tang, B. Z. Interdiscip. Med. 2023, 1, e20220011.
[58]	Qi, G.; Hu, F.; Kenry; Chong, K. C.; Wu, M.; Gan, Y. H.; Liu, B. Adv. Funct. Mater. 2020, 30, 2001338. doi: 10.1002/adfm.v30.31
[59]	Xin, H.; Lin, Q.; Sun, S.; Wang, Y.; Liu, B.; Wang, W.; Mao, Z. Wang, K. Aggregate 2025, 6, e709.
[60]	(a) Liu, S.; Wang, B.; Yu, Y.; Liu, Y.; Zhuang, Z.; Zhao, Z.; Feng, G.; Qin, A.; Tang, B. Z. ACS Nano 2022, 16, 9130. doi: 10.1021/acsnano.2c01206
	(b) Qi, G.; Hu, F. K.; Chong, K. C.; Wu, M.; Gan, Y. H.; Liu, B. Adv. Funct. Mater. 2020, 30, 2001338. doi: 10.1002/adfm.v30.31
[61]	Wang, P.; Wu, B.; Li, M.; Song, Y.; Chen, C.; Feng, G.; Mao, D.; Hu, F.; Liu, B. ACS Nano 2023, 17, 10365. doi: 10.1021/acsnano.3c00796
[62]	Tjampakasari, C. R.; Prasetyo, D. S.; Ningsih, I.; Kiranasari, A. Iran. J. Microbiol. 2022, 14, 24.
[63]	Zhou, K.; Du, L.; Ding, R.; Xu, L.; Shi, S.; Wang, S.; Wang, Z.; Zhang, G.; He, G.; Zhao, Z.; Tang, B. Z. Nat. Commun. 2024, 15, 10551. doi: 10.1038/s41467-024-55060-w
[64]	(a) Lesbats, J.; Brillac, A.; Reisz, J. A.; Mukherjee, P.; Lhuissier, C.; Fernández-Monreal, M.; Dupuy, J.-W.; Sequeira, A.; Tioli, G.; De La Calle Arregui, C.; Pinson, B.; Wendisch, D.; Rousseau, B.; Efeyan, A.; Sander, L. E.; D’Alessandro, A.; Garaude, J. Nature 2025, 640, 524. doi: 10.1038/s41586-025-08629-4
	(b) Qi, G.; Hu, F.; Kenry, L. S.; Wu, M.; Liu, B. Angew. Chem., Int. Ed. 2019, 58, 16229. doi: 10.1002/anie.v58.45
[65]	Zhang, J.; He, X.; Tang B. Z. ACS Nano 2024, 18, 3199. doi: 10.1021/acsnano.3c09695 pmid: 38227824
[66]	(a) Kathiravan, A.; Sundaravel, K.; Jaccob, M.; Dhinagaran, G.; Rameshkumar, A.; Ananth, D.; Sivasudha, T. J. Phy. Chem. B 2014, 118, 13573. doi: 10.1021/jp509697n
	(b) Yang, P.; Huang, H.; Xie, X. Environ. Pollut. 2023, 334. 121738.
	(c) Kathiravan, A.; Sundaravel, K.; Jaccob, M.; Dhinagaran, G.; Rameshkumar, A.; Ananth, A. D.; Sivasudha, T. J. Phys. Chem. B 2014, 118, 13573. doi: 10.1021/jp509697n
	(d) Zhou, C.; Jiang, M.; Du, J.; Bai, H.; Shan, G.; Kwok, R. T. K. Chau, J. H. C.; Zhang, J.; Lam, J. W. Y.; Huang, P.; Tang, B. Z. Chem. Sci. 2020, 11, 4730. doi: 10.1039/D0SC00256A
	(e) Ge, X.; Gao, M.; Situ, B.; Feng, W.; He, B.; He, X.; Li, S.; Ou, Z.; Zhong, Y.; Lin, Y.; Ye, X.; Hu, X.; Tang, B. Z.; Zheng, L. Mater. Chem. Front. 2020, 4, 957. doi: 10.1039/C9QM00732F
	(f) Hu, R.; Deng, Q.; Tang, Q.; Zhang, R.; Wang, L.; Situ, B.; Gui, C.; Wang, Z.; Tang, B. Z. Biomaterials 2021, 271, 120725. doi: 10.1016/j.biomaterials.2021.120725
[67]	Wang, B.; Wang, S.; Li, C.; Li, J.; Yi, M.; Lyu, J.; Gu, B.; Kwok, R. T. K.; Lam, J. W. Y.; Qin, A.; Tang, B. Z. Mater. Today Bio 2024, 29, 101329.

聚集诱导发光光敏剂用于光动力抗菌治疗

Aggregation-Induced Emission Photosensitizers for Photodynamic Antimicrobial Therapy

RichHTML

PDF

Knowledge

Abstract

Cite this article

share this article

Fig. & Tab. 14

References 67

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Bingyan Chen, Jie Sun, Linghong Xiong, Xuewen He. Fluorescence Light-Up Detection and Imaging of Atypical Nucleic Acid Structures [J]. Chinese Journal of Organic Chemistry, 2025, 45(11): 4082-4107.
[2]	Xue Bai, Yili Xie, Junyuan Li, Zihua Mo, Qing Wan. Design of High Efficiency Cationic Photosensitizer and Its Application in Low Irradiation Dose Photodynamic Antibacterial [J]. Chinese Journal of Organic Chemistry, 2025, 45(11): 4143-4151.
[3]	Jianye Yang, Pei Zhou, Qifei Shen, Peijuan Zhang, Yanzi Xu, Bingjie Zhao, Dongfeng Dang. Progress of Organic Radical Materials in Biomedical Applications [J]. Chinese Journal of Organic Chemistry, 2025, 45(11): 4013-4025.
[4]	Zixuan Dong, Junjun Su, Hongfei Pan, Xiangkui Ren, Zhijian Chen. Near-Infrared Aggregation-Induced Emission (AIE) Molecules Based on Coupling of Triarylamine-Modified Benzothiadiazole Units [J]. Chinese Journal of Organic Chemistry, 2025, 45(1): 205-211.
[5]	Yan Ou, Lin Lan, Zhengxiong Wang, Zhiming Wang, BenZhong Tang. Preparation of Aggregation-Induced Emission Nucleic Acid Probes and Study of Their Nucleic Acid Sensing Principles [J]. Chinese Journal of Organic Chemistry, 2024, 44(8): 2554-2562.
[6]	Yujie Yang, Wei Cao, Jikai Yu, Zhixia Zhang, Li Xu, Hua Wang. Synthesis of Donor-Acceptor (D-A) Typed Phenylcyclooctatetrathiophenes and Their Performances on Aggregation Induced Emission and High Pressure Luminescence [J]. Chinese Journal of Organic Chemistry, 2024, 44(8): 2495-2503.
[7]	Hanyu Jia, Yuewen Yu, Guangxue Feng, BenZhong Tang. Construction of Type I Aggregation-Induced Emission Photosensitizers for Photodynamic Therapy via Photoinduced Electron Transfer Mechanism [J]. Chinese Journal of Organic Chemistry, 2024, 44(8): 2530-2537.
[8]	Jidong Zhang, Yao Yang, Jie Zhang, Wei She. Detection of Zn(II) by Tetraphenylethyene Fluorescent Probe Based on Aggregation-Induced Emission (AIE)-Excited State Intramolecular Proton Transfer (ESIPT) Effect [J]. Chinese Journal of Organic Chemistry, 2024, 44(4): 1337-1342.
[9]	Chongyang Zeng, Ping Hu, Biqin Wang, Wenyan Fang, Keqing Zhao. Cyanostilbene Bridged Triphenylene Dyad Stimuli-Responsive Discotic Liquid Crystal: Synthesis, Properties and Applications [J]. Chinese Journal of Organic Chemistry, 2023, 43(9): 3287-3296.
[10]	Yang Zhao, Panpan Chen, Lizhi Han, Enju Wang. Aggregation-Induced Emission and Cell Imaging of Triphenylimidazole Derivatives [J]. Chinese Journal of Organic Chemistry, 2023, 43(7): 2454-2461.
[11]	Yuehua Zhang, Fei Nie, Lu Zhou, Xiaofeng Wang, Yuan Liu, Yanping Huo, Wencheng Chen, Zujin Zhao. Synthesis and Optoelectronic Studies of Thermally Activated Delayed Fluorescence Materials Based on Benzothiazolyl Ketones [J]. Chinese Journal of Organic Chemistry, 2023, 43(11): 3876-3887.
[12]	Meng Liu, Yanru Huang, Xiaofei Sun, Lijun Tang. An “Aggregation-Induced Emission+Excited-State Intramolecular Proton Transfer” Mechanisms-Based Benzothiazole Derived Fluorescent Probe and Its ClO^–Recognition [J]. Chinese Journal of Organic Chemistry, 2023, 43(1): 345-351.
[13]	Jidong Zhang, Wanlin Yan, Wenqiang Hu, Dian Guo, Dalong Zhang, Xiaoxin Quan, Xianpan Bu, Siyu Chen. Design and Synthesis of a Zn²⁺ Fluorescent Probe Based on Aggregation Induced Luminescence Properties [J]. Chinese Journal of Organic Chemistry, 2023, 43(1): 326-331.
[14]	Yangyang Li, Xiaofei Sun, Xiaoling Hu, Yuanyuan Ren, Keli Zhong, Xiaomei Yan, Lijun Tang. Synthesis of Triphenylamine Derivative and Its Recognition for Hg²⁺ with “OFF-ON” Fluorescence Response Based on Aggregation-Induced Emission (AIE) Mechanism [J]. Chinese Journal of Organic Chemistry, 2023, 43(1): 320-325.
[15]	Ze Guo, Di Wu, Lili Wang, Zheng Duan. BF₃•Et₂O Promoted Dienone-Phenol Type Rearrangement to Synthesize Phosphepine with Aggregation Induced Luminescence (AIE) Effect [J]. Chinese Journal of Organic Chemistry, 2022, 42(8): 2481-2487.