Research Progress in Radical-Mediated 1,n-Nitrogen Migration Reactions

doi:10.6023/cjoc202512013

Abstract

The radical-mediated 1,n-nitrogen migration reaction represents a novel strategy for skeleton rearrangement that enables the efficient intramolecular relocation of nitrogen-containing functional groups. As such, it has garnered significant attention for the precise synthesis of high-value nitrogen-containing compounds. This review summarizes three types of nitrogen migration reactions classified by the migration site, including 1,2-nitrogen migration, 1,3-nitrogen migration, and remote nitrogen migration, along with their applications in organic synthesis. Furthermore, prospects for future development in this field are discussed.

Key words: radical, nitrogen migration, rearrangement, asymmetric migration

Cite this article

Chen Jiahao, Zhan Beibei, Zhang Xiaheng. Research Progress in Radical-Mediated 1,n-Nitrogen Migration Reactions[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202512013.

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自由基介导的1,n-氮迁移反应研究进展