Advances in Asymmetric Double (Transfer) Hydrogenation of Conjugated Enones

doi:10.6023/cjoc202603008

Chinese Journal of Organic Chemistry Previous Articles Next Articles

共轭烯酮的不对称双(转移)氢化研究进展

秦观宝^a,b, 赵梦龙^b, 韩召斌^b,*, 丁奎岭^b,c,d,*

^a上海理工大学材料与化学学院上海 200093;
^b中国科学院上海有机化学研究所金属有机化学全国重点实验室上海 200032;
^c上海交通大学化学化工学院上海 200240;
^d上海交通大学变革性分子前沿科学中心上海 200240

收稿日期:2026-03-06 修回日期:2026-04-02
基金资助:
国家重点研发计划(2021YFA1500200), 国家自然科学基金(21872167), 上海市优秀学术/技术带头人计划(22XD1424800)资助项目..

Advances in Asymmetric Double (Transfer) Hydrogenation of Conjugated Enones

Qin Guanbao^a,b, Zhao Mneglong^b, Han Zhaobin^b,*, Ding Kuiling^b,c,d,*

^aSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093;
^bState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences, Shanghai 200032;
^cSchool of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240;
^dFrontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai 200240

Received:2026-03-06 Revised:2026-04-02
Contact: ^*E-mail: kding@sioc.ac.cn; zbhan@sioc.ac.cn
Supported by:
National Key R&D Program of China (2021YFA1500200), National Natural Science Foundation of China (No. 21872167). Program of Shanghai Academic/Technology Research Leader (22XD1424800).

Conjugated enones feature diverse structures and wide availability. Their asymmetric double (transfer) hydrogenation serves as an efficient strategy for the construction of secondary alcohols with multiple chiral centers. However, such transformations are highly challenging, as it requires the catalytic system to reduce two distinct types of unsaturated bonds while achieving precise control over multiple stereoselectivities. In recent years, remarkable progress has been made in this field through the development of new ligands and catalysts, the utilization of bimetallic relay catalytic systems, and the regulation of catalytic processes by additives. Based on the structural characteristics of conjugated enones, this review summarizes the advances in transition-metal-catalyzed asymmetric double hydrogenation and asymmetric double transfer hydrogenation of conjugated enones. The key challenges and future prospects in this area are also outlined and discussed.

Key words: conjugated enone, asymmetric hydrogenation, asymmetric transfer hydrogenation, transition metal

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Qin Guanbao, Zhao Mneglong, Han Zhaobin, Ding Kuiling. Advances in Asymmetric Double (Transfer) Hydrogenation of Conjugated Enones[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202603008.

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共轭烯酮的不对称双(转移)氢化研究进展

Advances in Asymmetric Double (Transfer) Hydrogenation of Conjugated Enones

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