Synthesis and Application of a Fluorescence Turn-on Probe for Hydrogen Sulfide Detection

doi:10.6023/cjoc202603030

Chinese Journal of Organic Chemistry

ARTICLE

一种用于硫化氢检测的荧光开启型探针的合成及应用

王龙¹, 蒙亚男¹, 任睿祺, 田明玉^*, 汤立军^*

渤海大学化学学院辽宁锦州 121013

收稿日期:2026-04-24 修回日期:2026-07-09
作者简介:¹共同第一作者.

Synthesis and Application of a Fluorescence Turn-on Probe for Hydrogen Sulfide Detection

Wang Long¹, Meng Yanan¹, Ren Ruiqi, Tian Mingyu^*, Tang Lijun^*

College of Chemistry, Bohai University, Jinzhou, Liaoning 121013

Received:2026-04-24 Revised:2026-07-09
Contact: ^*E-mail: tianmingyu@bhu.edu.cn; ljtang@bhu.edu.cn
About author:¹These authors contributed equally to this work
Supported by:
National Natural Science Foundation of China (No. 22278038), the Program for Distinguished Professor of Liaoning Province.

1. .doc(1080KB)

Abstract

Hydrogen sulfide (H₂S) is not only a toxic environmental pollutant (commonly found in food spoilage and industrial waste gas) but also an important signaling molecule in organisms. Therefore, it is necessary to develop an effective method to detect hydrogen sulfide. In this paper, TPAB-OH with high fluorescence quantum yield (Φ = 35.6%) was designed and synthesized by combining 4-(diphenylamino)-3-hydroxy-[1,1-biphenyl]-4-formaldehyde (TPA-CHO) with 2-aminobenzenethiol. Compound TPAB-OH reacted with 2, 4-dinitrofluorobenzene to produce a new probe TPAB-HS, which has the advantages of a wide pH range (4~12), fast response (10 min), high signal-to-noise ratio and low detection limit (8.56 × 10^-7 mol/L). In addition, the probe TPAB-HS is also suitable for the detection of HS^- in human breast cancer cells (MCF-7), actual water samples and food samples.

Key words: Triphenylamine derivatives, Fluorescence probe, Hydrogen sulfide, Food samples, Fluorescence imaging

Cite this article

Wang Long, Meng Yanan, Ren Ruiqi, Tian Mingyu, Tang Lijun. Synthesis and Application of a Fluorescence Turn-on Probe for Hydrogen Sulfide Detection[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202603030.

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一种用于硫化氢检测的荧光开启型探针的合成及应用

Synthesis and Application of a Fluorescence Turn-on Probe for Hydrogen Sulfide Detection

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