As a green and efficient strategy for the C—H functionalization of heterocyclic compounds, the electrochemical Minisci reaction has attracted considerable attention in the fields of organic synthesis and pharmaceutical research in recent years, owing to its advantages such as no need for additional oxidants, mild reaction conditions, and high atom economy. The core of this reaction lies in regulating radical generation via electrode processes to achieve the selective addition of nucleo-philic carbon radicals to protonated electron-deficient heterocycles, which effectively addresses the limitations of the traditional Minisci reaction, including a narrow substrate scope and numerous by-products. Recent research highlights also involve the exploration of strategies such as the construction of multicomponent systems and photoelectric synergistic catalytic systems, which have significantly expanded the reaction applicability and application scenarios. Most existing reviews cover research prior to 2022 or photoinduced systems, and lack a comprehensive summary of the new strategies and advances in electrochemically driven reactions in recent years. This work systematically reviews the latest research advances in the Minisci reaction under electrochemical conditions since 2022, providing a reference for molecular synthesis and structural modification in related fields.

Key words: Minisci reaction, electrochemical synthesis, hydrogen atom transfer (HAT), radical addition