Chinese Journal of Organic Chemistry Previous Articles     Next Articles

N-乙烯基酰胺参与的环化反应研究进展

邵长卿a, 林凯贤a†, 熊毅a†, 何晓雨a,*, 邹有全a,*   

  1. a武汉大学药学院 组合生物合成与新药发现教育部重点实验室,湖北武汉 430071
  • 收稿日期:2026-04-20 修回日期:2026-05-13
  • 基金资助:
    中央高校基本科研业务费(No.2042025kf0067)/武汉大学人才启动基金(No.691000002)和武汉光化学技术研究院基金(No.GHY2024PY002)资助项目.

Recent Advances in Cyclization Reactions using N-Vinylamides

Chang-Qing Shaoa, Kai-Xian Lina†, Yi Xionga†, Xiao-Yu Hea,*, You-Quan Zoua,*   

  1. aSchool of Pharmaceutical Sciences, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Wuhan University, Hubei Wuhan 430071
  • Received:2026-04-20 Revised:2026-05-13
  • Contact: *E-mail: xiaoyuhe@whu.edu.cn; youquanzou@whu.edu.cn
  • About author:These authors contributed equally to this work.
  • Supported by:
    Fundamental Research Funds for the Central Universities (No.2042025kf0067), the start-up funding from Wuhan University (No.691000002), and the Wuhan Institute of Photochemistry and Technology Grant (No.GHY2024PY002).

N-Vinylamides are an important class of synthetic building blocks, which are widely used in organic synthesis. Their unique structure, strong reactivity, and diverse reaction pathways make them ideal substrates for constructing cyclic frameworks. This review summarizes the recent progresses on cyclization reactions involving N-vinylamides to construct aminocyclopropanes, oxazolines, oxazoles, pyridines, and other cyclic compounds. The reaction mechanisms, substrate scope, stereoselectivity control, and the application of the products are also discussed.

Key words: Enamide, cyclization/cycloaddition reaction, aminocyclopropane, heterocyclic compounds, stereoselectivity