Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (7): 2136-2146.DOI: 10.6023/cjoc202401015 Previous Articles     Next Articles

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水溶液中的Minisci反应研究进展

王文贵, 王守锋*()   

  1. 济南大学化学化工学院 山东省氟化学化工材料重点实验室 济南 250022
  • 收稿日期:2024-01-15 修回日期:2024-03-05 发布日期:2024-03-28
  • 基金资助:
    国家自然科学基金(31972850)

Recent Advances of Minisci Reactions in Aqueous Solution

Wengui Wang, Shoufeng Wang()   

  1. Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022
  • Received:2024-01-15 Revised:2024-03-05 Published:2024-03-28
  • Contact: E-mail: chm_wangsf@ujn.edu.cn
  • Supported by:
    National Natural Science Foundation of China(31972850)

Minisci reaction is a convenient method for the functionalization of C—H in electron-defficient N-heterocycles. Different substituents could be introduced onto heterocycles through Minisci reaction, such as alkyl, acyl, silyl and alkylthio, etc. Water is eco-friendly and an ideal medium in organic synthesis, which has been applied in Minisci reaction. Recent progress in Minisci reaction in aqueous solution is reviewed herein. Minisci reaction is a convenient method for the functionalization of electron-defficient N-heterocycles. Different substituents could be introduced onto heterocycles through Minisci reaction, such as alkyl, acyl, silyl and alkylthio, boryl, etc. Thus, Minisci reaction is a powerful toolbox for the synthesis of substituted N-heterocylces. Water is eco-friendly and an ideal medium in organic synthesis, which has been applied in Minisci reaction. Although water was used from the discovery of Minisci reaction, Minisci reaction in aqueous solution is still underdeveloped. The recent progress in Minisci reaction in aqueous solution, including alkylation, arylation and acylation, is reviewed according to different radical precursors.

Key words: Minisci reaction, radical, aqueous solution, heterocycle