Research Progress on Reactions of Sulfur Ylides via Metal Carbene Intermediates

doi:10.6023/cjoc202606023

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经过渡金属卡宾中间体的硫叶立德反应研究进展

何卫保^a, 易荣楠^b,c,*, 伍智林^d,*, 何卫民^d,*

^a湖南化工职业技术学院技术与职业教育研究中心株洲 412000;
^b湖南警察学院食药环及毒品检验技术湖南省普通高等学校重点实验室长沙 410138;
^c南京林业大学化学工程学院南京 210037;
^d南华大学化学化工学院衡阳 421001

收稿日期:2026-06-20 修回日期:2026-07-20
基金资助:
湖南省自然科学基金(No. 2026JJ90135), 湖南省教育厅科学研究项目(No. 25A0703), 长沙市自然科学基金 (No.104872) 资助项目.

Research Progress on Reactions of Sulfur Ylides via Metal Carbene Intermediates

He Weibao^a, Yi, Rongnan^b,c,*, Wu, Zhilin^d,*, He, Weimin^d,*

^aResearch Center for Technical and Vocational Education Studies, Hunan Chemical Vocational Technology College, Zhuzhou 412000;
^bKey Laboratory of Food & Environment & Drug Monitoring and Testing of Universities in Hunan Province, Hunan Police Academy, Changsha 410138;
^cCollege of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China;
^dSchool of Chemistry and Chemical Engineering, University of South China, Hengyang 421001

Received:2026-06-20 Revised:2026-07-20
Contact: ^*E-mail: yrn@hnu.edu.cn, wuzhilin@usc.edu.cn; weiminhe@usc.edu.cn.
Supported by:
Hunan Provincial Natural Science Foundation (No. 2026JJ90135), the Scientific Research Fund of Hunan Provincial Education Department (No. 25A0703) and the Changsha Natural Science Foundation (No.104872)

Sulfur ylides are highly valuable active intermediates in organic synthesis and are widely employed for the construction of complex molecules, natural products and pharmaceutical skeletons. Transition metal carbenes are organometallic active species formed by the covalent or coordinate bonding between carbene carbons and transition metals. A double bond exists between the central metal and the carbene carbon, which endows the carbene carbon with high reactivity. Transition metals can directly coordinate with sulfur ylides to generate metal carbene intermediates. Alternatively, transition metals first react with diazo compounds or other precursors to form metal carbenes, which are then trapped by sulfur-containing compounds to produce sulfur ylides for subsequent diverse reactions. This paper systematically reviews the research progress of sulfur ylide reactions proceeding via transition metal carbene intermediates since 2022. Classified by typical transformations including cyclization, insertion, rearrangement and other reactions, this article elaborates on their synthetic strategies, reaction mechanisms and substrate scope in detail.

Key words: sulfur ylide, transition metal, carbene, research progress

Cite this article

He Weibao, Yi, Rongnan, Wu, Zhilin, He, Weimin. Research Progress on Reactions of Sulfur Ylides via Metal Carbene Intermediates[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202606023.

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经过渡金属卡宾中间体的硫叶立德反应研究进展

Research Progress on Reactions of Sulfur Ylides via Metal Carbene Intermediates

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