Chin. J. Org. Chem. ›› 1999, Vol. 19 ›› Issue (3): 271-277. Previous Articles     Next Articles

Original Articles

吡咯烷类手性二胺配体N-烷基化物的简易合成法

刘志煜;杨家德   

  1. 中国科学院上海有机化学研究所.上海(200032)
  • 发布日期:1999-06-25

A facile synthesis of (S^2-[(N-alkylated pyrrolidin-1-ylmethyl]- pyrrolidine and related chiral diamine ligands

Liu Zhiyu;Yang Jiade   

  1. Shanghai Inst Organ Chem., CAS.Shanghai(200032)
  • Published:1999-06-25

The title ligands are easily synthesized by reductive amination of the corresponding aldehydes with (S)-(+)-2-(1-pyrrolidino) methyl- pyrrolidine and related amines using zinc chloride and potassium borohydride or sodium borohydride in dichloromethane at room temperature.

Key words: ALKYLATION, PYRROLIDINE, DIAMINE, CHIRALITY, SYNTHESIS METHODS

CLC Number: