A series of conjugated eneyne compounds 3b, 3c and 3d were prepared. After treating them with halo-substituted eneyne compounds 5a, 5b, 5c, 5d and 5f, the enediyne units conjugated with cyclopatene derivatives were successfully constructed. The dienediyne structure is general present in antitumor antibiotics C-1027-chromophore and Kedarcidine- chromophore. In the meantime, their cross-coupling reaction under palladium-catalyzed conditions was in investigated detail, and it was found that the reactivity decrease in the order of iodo-substituted alkenes>bromide>chloride.

Key words: SYNTHESIS, CHROMOPHOR, FUNCTIONAL GROUP