An efficient transformation of methyl gallate to eusiderin G7, a neolignan with 1,4-benzodioxane nuclei, in six steps with 24% overall yield is reported. This route is distinctly shorter, more economic and efficient than any of the previous approaches to the target reported in the literature. the key step is a cyclization of an dihydroxy intermediate 4 catalysted by a strong acid ion exchange resin to give 1,4-benzodioxane skeleton.

Key words: LIGNANS, TOTAL SYNTHESIS