Studies on Chemical Constituents of the Soft Coral Scleronephthya sp. from the South China Sea

Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (10): 1233-1238. Previous Articles Next Articles

中国南海软珊瑚Scleronephthya sp.化学成分的研究

严小红^a, 郭跃伟^*,a, 朱兴族^a, MOLLO Ernesto^b, CIMINO Guido^b

^a中国科学院上海生命科学研究院药物研究所国家新药研究重点实验室上海 201203;
^bIstituto di Chimica Biomolecolare-CNR, 80078 (Puzzuoli NA), Italy

收稿日期:2004-01-13 修回日期:2004-04-19 接受日期:2004-04-19 发布日期:2022-09-20
基金资助:
国家海洋863计划(Nos. 2001AA620403, 2003AA624030)、国家杰出青年基金(No. 30125044)、中-意双边国际合作基金(CNR/CAS Joint Projects 2001/2004)资助项目.

Studies on Chemical Constituents of the Soft Coral Scleronephthya sp. from the South China Sea

YAN Xiao-Hong^a, GUO Yue-Wei^*,a, ZHU Xing-Zu^a, MOLLO Ernesto^b, CIMINO Guido^b

^aState Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203;
^bIstituto di Chimica Biomolecolare-CNR, (Puzzuoli NA) 80078, Italy

Received:2004-01-13 Revised:2004-04-19 Accepted:2004-04-19 Published:2022-09-20
Contact: * E-mail: ywguo@mail.shcnc.ac.cn

Abstract

Thirteen compounds have been isolated from Et₂O soluble fraction of the soft coral Scleronephthya sp. The structures of these compounds were characterizedby ¹H NMR, ¹³C NMR, HMQC, HMBC, ¹H-¹H COSY, EIMS and compared with the data reported in literature as pregna-20-en-3β-O-acetate (1), pregna-5,20-dien-3β-O-acetate (2), pregna-20-en-3-one (3), 1,2-epoxypregna-20-en-3-one (4), pregna-1,20-dien-3-one (5), pregna-1-en-3-one-20-S-methyl-21-O-acetate (6), pregna-1-en-3-one-20β-O-acetate (7), cholest-1-en-3,22-dione (8), cholest-1,24-en-3-one-22,23-diol (9), O-methylisogrifolin (10), (1R,3S,4S,7E,11E)-3α,4α-epoxycembra-7,11,15-triene (11),(3R,3R')-astaxanthin (12) and 6-bromoindole-3-carboxylic acid (13), respectively. Among them, compounds 4, 6 and 10 were first isolated from natural sources. Spectroscopicdata of compounds 6, 7 and 10 were first reported, and their¹³C NMR data were assigned by 2D NMR. This paper also discussed the possible biosynthesis of compounds 1～7. Compounds 6 and 7 showinhibitory activity to HELA cell line, and their IC₅₀ values are 3.3 and 6.3 mol/L, respectively. Compound 7 also shows inhibitory activity to BEL7402 and HL-60 cel line, and its IC₅₀ value is 3.1 and 0.26 mol/L, respectively. Compound 11 shows inhibitory activity to COX-2 with IC₅₀of 0.455 mol/L.

Key words: Soft coral, Scleronephthya sp., chemical constituent

Cite this article

YAN Xiao-Hong, GUO Yue-Wei, ZHU Xing-Zu, MOLLO Ernesto, CIMINO Guido. Studies on Chemical Constituents of the Soft Coral Scleronephthya sp. from the South China Sea[J]. Chinese Journal of Organic Chemistry, 2004, 24(10): 1233-1238.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

[1]	Feng Chan, Wei Xia, Hu Jinshan, Wang Siyu, Liu Bingxin, Xie Zhenyu, Rong Li, Li Xiaohui, Zhang Cuixian. Researches on the Subergane-Type Sesquiterpenes from the Soft Coral-Derived Fungus Aspergillus sp. EGF15-0-3 [J]. Chinese Journal of Organic Chemistry, 2020, 40(5): 1275-1280.
[2]	Wang Jutaoa, Ma Zonghuia, Wang Guokaia, Xu Fengqinga, Yu Yang, Wang Ganga, Liu Jinsong. Secondary Metabolites of Endophytic Fungus Penicillium mariae-crucis from Paeonia lactiflora Pall [J]. Chin. J. Org. Chem., 2019, 39(4): 1136-1141.
[3]	Wang Kou, Wang Yun, Wang Ziming, Ding Linfen, Hu Jianlin, Chen Ji. Three New Polycyclic Polyprenylated Acylphloroglucinols from Hypericum lagarocladum [J]. Chin. J. Org. Chem., 2019, 39(3): 848-851.
[4]	Shao Taiming, Li Xiaobao, Qi Cuicui, Chen Guangying, Song Xiaoping, Han Changri, Zheng Caijuan. Chemical Constituents of Isoflavonoids from Roots of Ficus auriculata [J]. Chin. J. Org. Chem., 2018, 38(3): 710-714.
[5]	Xu Fengqing, Fan Weiwei, Zi Chengting, Zhou Jun, Hu Jiangmiao. Three New Glycosides from the Stems and Leaves of Passiflora edulis [J]. Chin. J. Org. Chem., 2018, 38(2): 526-530.
[6]	Wang Guokai, Sun Yunpeng, Wang Zheng, Zhang Nan, Wang Gang, Zhou Zhongyu, Liu Jinsong. Two New Flavonoids from Kalimeris integrifolia [J]. Chin. J. Org. Chem., 2017, 37(4): 1016-1019.
[7]	Wang Lijun, Lau Choiwan, Xiong Juan, Hu Jinfeng. Further Chemical Constituents from the Rare Chloranthaceae Plant Chloranthus sessilifolius [J]. Chin. J. Org. Chem., 2016, 36(7): 1677-1680.
[8]	Xiao Shiji, Xu Delin, Fu Shaobin, Zhang Maosheng, Ding Lisheng, Zhou Yan. Two New Nitrogen Compounds from Gymnotheca involucrata [J]. Chin. J. Org. Chem., 2016, 36(10): 2496-2498.
[9]	Wang Yan, Chen Wenhao, Chen Guangying, Song Xiaoping, Zhang Dashuai, Fu Bo, Chen Yi. Anthraquinones from the Leaves of Saprosma hainanense [J]. Chin. J. Org. Chem., 2014, 34(3): 522-525.
[10]	Xiong Juan, Huang Ya, Tang Yu, You Mei, Hu Jinfeng. Pentacyclic Triterpenoids from the Roots of Rhodomyrtus tomentosa [J]. Chin. J. Org. Chem., 2013, 33(06): 1304-1308.
[11]	Ma Yangmin, Wu Hao. Chemical Constituents of Sambucus L. [J]. Chin. J. Org. Chem., 2012, 32(11): 2063-2072.
[12]	LIAO Xiao-Jian, XU Shi-Hai, LIN Hui. Isolation and Identification of Two Tetrahydroxylated Sterols with Cytotoxic Activity [J]. Chin. J. Org. Chem., 2010, 30(05): 749-752.
[13]	LI Fu-Shuang, XU Kang-Beng, YUAN Shou-Hong, YA Dong-Lan, LIU Rang-Ru, TAN Jian-Bing, CENG Guang-Yao, ZHOU Ying-Jun, TAN Gui-Shan. Macrocyclic Diterpenes from Boswellia carterii Birdwood (Frankincense) [J]. Chin. J. Org. Chem., 2010, 30(01): 107-111.
[14]	LI Kun, DIAO Yun-Feng, WANG Meng-Dong, YANG Song-Song, ZHANG Hou-Li, HUANG Shan-Shan, YANG Gong. Chemical Constituents of the Fruits of Physalis Alkekengi L。var。franchetii (Mast.) Makino [J]. Chin. J. Org. Chem., 2010, 30(01): 128-131.
[15]	LAN Wen-Jian,SU Jing-Yu²,ZENG Long-Mei*^,2. Isolation and¹H, ¹³C NMR Assignments for Methyl Sartortuoate [J]. Chin. J. Org. Chem., 2005, 25(11): 1465-1468.

中国南海软珊瑚Scleronephthya sp.化学成分的研究

Studies on Chemical Constituents of the Soft Coral Scleronephthya sp. from the South China Sea

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments