Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (3): 334-337. Previous Articles     Next Articles

微波作用下1,5-苯并硫氮杂䓬-α-溴代-β-内酰胺衍生物的合成

张萍, 李文红, 李媛*   

  1. 河北师范大学化学系 石家庄 050016
  • 收稿日期:2003-07-17 修回日期:2003-09-19 接受日期:2003-10-08 发布日期:2022-09-20

Synthesis of α-Bromo-β-lactam Derivatives of 1,5-Benzothiazepines under Microwave Irradition

ZHANG, Ping, LI, Wen-Hong, LI, Yuan*   

  1. Department of Chemistry, Hebei Normal University, Shijiazhuang 050016
  • Received:2003-07-17 Revised:2003-09-19 Accepted:2003-10-08 Published:2022-09-20
  • Contact: *E-mail: lgchen@tju.edu.cn; Tel & Fax: 022-27406314.

Five new α-bromo-β-lactam derivatives of 1,5-benzothiazepines were synthesized by the reaction of 1,5-benzothiazepines with bromoacetyl chloride under microwave irradiation. Nine β-lactam derivatives were also synthesized which had been obtained under routine method. Their structures were confirmed by 1H NMR, IR, MS, and elemental analysis. The optimal conditions of this kind of reaction were studied.

Key words: 1,5-benzothiazepine, β-lactam, microwave irradiation