Yb(OTf)3 Catalyzed Mannich Reaction of Acetophe-none withAromatic Aldehydes and Aromatic Amines: Three Component One-pot Synthesis of β-Amino Ketone Derivatives

Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (05): 591-594. Previous Articles Next Articles

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Yb(OTf)₃催化苯乙酮、芳香醛和芳香胺的Mannich反应: 三组分“一锅法”合成β-氨基酮衍生物

王利民*，韩建伟，盛佳，樊兆玉，田禾

(华东理工大学精细化工研究所结构可控先进功能材料教育部重点实验室上海 200237)

收稿日期:2004-08-02 修回日期:2004-11-23 发布日期:2004-04-30
通讯作者: 王利民

Yb(OTf)₃ Catalyzed Mannich Reaction of Acetophe-none withAromatic Aldehydes and Aromatic Amines: Three Component One-pot Synthesis of β-Amino Ketone Derivatives

WANG Li-Min*,HAN Jian-Wei,SHENG Jia,FAN Zhao-Yu,TIAN He

(Institute of Fine Chemicals, Laboratory for Advanced Materials, East China University of Science and Technology,
Shanghai 200237)

Received:2004-08-02 Revised:2004-11-23 Published:2004-04-30
Contact: WANG Li-Min

Abstract

The three component “one-pot” Mannich reaction of acetophenone with aromatic aldehydes and aromatic amines catalyzed by Yb(OTf)₃ afforded the corresponding β-amino ketone derivatives in high yields under mild conditions. The catalyst Yb(OTf)₃ was recycled easily and thus regarded as environmentally-friendly catalyst.

Key words: Mannich reaction, Yb(OTf)₃, aromatic aldehyde, β-amino ketone derivative, aromatic amine

Cite this article

WANG Li-Min*,HAN Jian-Wei,SHENG Jia,FAN Zhao-Yu,TIAN He. Yb(OTf)₃ Catalyzed Mannich Reaction of Acetophe-none withAromatic Aldehydes and Aromatic Amines: Three Component One-pot Synthesis of β-Amino Ketone Derivatives[J]. Chin. J. Org. Chem., 2005, 25(05): 591-594.

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Yb(OTf)₃催化苯乙酮、芳香醛和芳香胺的Mannich反应: 三组分“一锅法”合成β-氨基酮衍生物

Yb(OTf)₃ Catalyzed Mannich Reaction of Acetophe-none withAromatic Aldehydes and Aromatic Amines: Three Component One-pot Synthesis of β-Amino Ketone Derivatives

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Yb(OTf)3催化苯乙酮、芳香醛和芳香胺的Mannich反应: 三组分“一锅法”合成β-氨基酮衍生物