Purification Technique for Liquid-Phase Combinatorial Synthesis

Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (12): 1453-1462. Next Articles

Review

液相组合合成的纯化方法

王文昭，方唯硕*

(中国医学科学院药物研究所中草药物质基础与资源利用教育部重点实验室北京 100050)

收稿日期:2006-11-29 修回日期:2007-03-10 发布日期:2007-12-04
通讯作者: 方唯硕

Purification Technique for Liquid-Phase Combinatorial Synthesis

WANG Wen-Zhao, FANG Wei-Shuo*

(Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical
College), Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050)

Received:2006-11-29 Revised:2007-03-10 Published:2007-12-04
Contact: FANG Wei-Shuo

Abstract

Different purification techniques during the past eight years for liquid-phase parallel synthesis and combinatorial synthesis, including the application of soluble polymer supports, fluorous technologies, ionic liquids, solid-phase binding reagents and oligoethylene glycol sorting tags, are summarized. In this review, basic principles and applications for these techniques, with an emphasis on the separation and purification of targeted products, are discussed.

Key words: liquid-phase parallel synthesis, purification strategy, fluorous technology, soluble polymer support, oligoethylene glycol sorting tag, solid-supported reagent, ionic liquid, liquid-phase combinatorial synthesis

Cite this article

WANG Wen-Zhao, FANG Wei-Shuo*. Purification Technique for Liquid-Phase Combinatorial Synthesis[J]. Chin. J. Org. Chem., 2007, 27(12): 1453-1462.

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液相组合合成的纯化方法

Purification Technique for Liquid-Phase Combinatorial Synthesis

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