Application of Chiral (Thio)urea Derivatives in Asymmet-ricOrganocatalysis

Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (12): 1491-1501. Previous Articles Next Articles

Review

手性(硫)脲衍生物在不对称有机催化反应中的应用

吴秋华，高勇军，李芝，王俊敏，王春*
马晶军，宋双居

(河北农业大学理学院河北省生物无机化学重点实验室保定 071001)

收稿日期:2007-10-23 修回日期:2007-04-03 发布日期:2007-12-04
通讯作者: 王春

Application of Chiral (Thio)urea Derivatives in Asymmet-ricOrganocatalysis

WU Qiu-Hua, GAO Yong-Jun, LI Zhi, WANG Jun-Min, WANG Chun*
MA Jing-Jun, SONG Shuang-Ju

(Hebei Key Laboratory of Bioinorganic Chemistry, College of Sciences, Agricultural University of He-bei, Baoding 071001)

Received:2007-10-23 Revised:2007-04-03 Published:2007-12-04
Contact: WANG Chun

Abstract

Chiral (thio)urea derivatives are very effective organocatalysts for the nuclephilic addition reactions of imines, aldehydes, electron-deficient olefins, etc. They have been successfully applied in varieties of enantioselective organic reactions, such as asymmetric Strecker, Michael addition, Mannich, Baylis-Hillman, Acyl-Pictet-Spengler and Henry reactions as well as the dynamic kinetic resolution. Chiral (thio)urea derivatives are rapidly emerging as versatile, high catalytic active, low catalyst loading, excellent enantioselective, high functional group tolerant, ease of prepared/modified organocatalyst for the promotion of a wide range of synthetically useful asymmetric processes. The application of chiral (thio)urea derivatives in asymmetric organocatalysis is reviewed in this paper.

Key words: enantioselectivity, chiral urea and thiourea, asymmetric organocatalysis

Cite this article

WU Qiu-Hua, GAO Yong-Jun, LI Zhi, WANG Jun-Min, WANG Chun*
MA Jing-Jun, SONG Shuang-Ju. Application of Chiral (Thio)urea Derivatives in Asymmet-ricOrganocatalysis[J]. Chin. J. Org. Chem., 2007, 27(12): 1491-1501.

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手性(硫)脲衍生物在不对称有机催化反应中的应用

Application of Chiral (Thio)urea Derivatives in Asymmet-ricOrganocatalysis

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