Microwave Assisted Synthesis and Antibacterial Study of 3-Naphthyl-2-[(un)substituted phenyl]-1,3-thiazolidin-4-ones

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (06): 1092-1096. Previous Articles Next Articles

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新型3-萘基-1,3-噻唑烷-4-酮衍生物的微波促进合成及其抗菌活性研究

陈华^a，白洁^a，赵莲^a，苑香果^a，李小六^*,a，曹克强b

(a河北大学化学与环境科学学院保定 071002) (b河北农业大学植物保护学院保定 071001)

收稿日期:2007-09-26 修回日期:2007-11-07 发布日期:2008-06-26
通讯作者: 李小六

Microwave Assisted Synthesis and Antibacterial Study of 3-Naphthyl-2-[(un)substituted phenyl]-1,3-thiazolidin-4-ones

CHEN Hua^a,BAI, Jie^{^a,}ZHAO Lian^a,YUAN Xiang-Guo^a,LI Xiao-Liu*^a,CAO Ke-Qiangb

(a College of Chemistry and Environmental Science, Hebei University, Baoding 071002) (b College of Plant Protection, Hebei Agricultural University, Baoding 071001)

Received:2007-09-26 Revised:2007-11-07 Published:2008-06-26
Contact: LI Xiao-Liu

Abstract

A series of 3-naphthyl-2-[(un)substituted phenyl]-1,3-thiazolidin-4-ones were synthesized by the three-component one-pot cyclocondensation of naphthylamine, aromatic aldehyde and 2-mercaptoacetic acid using a microwave-assisted method in the presence of DMAP/DCC. This reaction has such advantages as short reaction time, simple procedure and mild condition. The structures of the synthesized compounds were confirmed by IR, NMR, MS spectra and elemental analysis. Antibacterial (Pseudomonas springae pv. lachrymans (Smith et Bryan) Young, Dye & Wilkie, Botrytis cinerea Pers., and Sphaerotheca fusca Blum.) activities of the compounds were evaluated, and some of them showed notable inhibition against Sphaerotheca fusca Blum.

Key words: thiazolidin-4-one, antibacterial activity, microwave-assisted

Cite this article

CHEN Hua^a,BAI, Jie^{^a,}ZHAO Lian^a,YUAN Xiang-Guo^a,LI Xiao-Liu*^a,CAO Ke-Qiangb. Microwave Assisted Synthesis and Antibacterial Study of 3-Naphthyl-2-[(un)substituted phenyl]-1,3-thiazolidin-4-ones[J]. Chin. J. Org. Chem., 2008, 28(06): 1092-1096.

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新型3-萘基-1,3-噻唑烷-4-酮衍生物的微波促进合成及其抗菌活性研究

Microwave Assisted Synthesis and Antibacterial Study of 3-Naphthyl-2-[(un)substituted phenyl]-1,3-thiazolidin-4-ones

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