Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (11): 1911-1917. Previous Articles     Next Articles

Review

ent-贝壳杉烷型二萜化合物的细胞毒活性研究进展

张大永; 李子元 ; 施连勇; 吴晓明*; 华维一   

  1. (中国药科大学药学院 南京 210009)
  • 收稿日期:2007-11-20 修回日期:2008-04-14 发布日期:2008-11-18
  • 通讯作者: 吴晓明

Advances in Research on Cytotoxinic Activity of ent-Kaurane Diterpenoids

ZHANG, Da-Yong; LI, Zi-Yuan ; SHI, Lian-Yong; WU, Xiao-Ming*; HUA, Wei-Yi   

  1. (School of Pharmacy, China Pharmaceutical University, Nanjing 210009)
  • Received:2007-11-20 Revised:2008-04-14 Published:2008-11-18
  • Contact: WU, Xiao-Ming

The recent progress in natural or synthetical ent-kaurane diterpenoids possessing definite cytotoxinic activity is reviewed in detail, the structure-activity relationships, mechanisms and selectivities upon multiple human tumor cell lines are discussed, the potential for the development as prospective anti-tumor drugs is evaluated, some temporary problems are summarized, and the prospects of the development and the directions of the research are anticipated.

Key words: ent-kaurane diterpenoid, structure-activity relationship, selectivity to tumor cell line, mechanism, cytotoxinic activity