New Advances in the Synthesis of Biginelli 3,4-Dihydropyrimidin-2(1H)-one Derivatives

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (06): 876-883. Previous Articles Next Articles

Review

Biginelli 3,4-二氢嘧啶-2-酮衍生物的合成研究新进展

权正军 ; 张彰 ; 达玉霞; 王喜存*

(西北师范大学化学化工学院甘肃省高分子材料重点实验室兰州 730070)

收稿日期:2008-06-26 修回日期:2008-09-12 发布日期:2009-06-20
通讯作者: 王喜存

New Advances in the Synthesis of Biginelli 3,4-Dihydropyrimidin-2(1H)-one Derivatives

Quan, Zhengjun ; Zhang, Zhang; Da, Yuxia; Wang, Xicun*

(Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering,
Northwest Normal University, Lanzhou 730070)

Received:2008-06-26 Revised:2008-09-12 Published:2009-06-20
Contact: Wang, Xicun

Abstract

In 1893, Biginelli reported the first synthesis of 3,4-dihydropyrimidin-2(1H)-ones (DHPM) by a very simple one-pot condensation reaction of an aromatic aldehyde, urea and ethyl acetoacetate. It has been established that Biginelli-type dihydropyrimidinones present interesting pharmacological properties assiociated with good reactivities. In this article, the recent developments in the synthesis of DHPM derivatives, asymmetric Biginelli compounds and natural products using Biginelli reaction have been reviewed.

Key words: 3,4-dihydropyrimidin-2(1H)-one, asymmetric synthesis, natu-ral product synthes, Biginelli condensation reaction

Cite this article

Quan, Zhengjun ; Zhang, Zhang; Da, Yuxia; Wang, Xicun*. New Advances in the Synthesis of Biginelli 3,4-Dihydropyrimidin-2(1H)-one Derivatives[J]. Chin. J. Org. Chem., 2009, 29(06): 876-883.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

[1]	Shihang Yu, Jiawei Liu, Biyu An, Qinghua Bian, Min Wang, Jiangchun Zhong. Asymmetric Synthesis of the Contact Sex Pheromone of Neoclytus acuminatus acuminatus (Fabricius) [J]. Chinese Journal of Organic Chemistry, 2024, 44(1): 301-308.
[2]	Huakun Wang, Xiaolong Ren, Yining Xuan. Study of the Halide Salt Catalyzed [3＋2] Cycloaddition of α,β-Epoxy Carboxylate with Isocyanate [J]. Chinese Journal of Organic Chemistry, 2024, 44(1): 251-258.
[3]	Yuchao Wang, Jinbiao Liu, Zhitao He. Palladium-Catalyzed Asymmetric Hydrofunctionalizations of Conjugated Dienes [J]. Chinese Journal of Organic Chemistry, 2023, 43(8): 2614-2627.
[4]	Tingyu Song, Ran Li, Lihua Huang, Shikun Jia, Guangjian Mei. Catalytic Asymmetric Synthesis of N—N Atropisomers [J]. Chinese Journal of Organic Chemistry, 2023, 43(6): 1977-1990.
[5]	Cheng Luo, Yanli Yin, Zhiyong Jiang. Recent Advances in Asymmetric Synthesis of P-Chiral Phosphine Oxides [J]. Chinese Journal of Organic Chemistry, 2023, 43(6): 1963-1976.
[6]	Ling Meng, Jun Wang. Research Progress on Synthesis of Thioflavonoids [J]. Chinese Journal of Organic Chemistry, 2023, 43(3): 873-891.
[7]	Huaiyuan Zhang, Nuo Xu, Rongping Tang, Xingli Shi. Recent Advances in Asymmetric Dearomatization Reactions Induced by Chiral Hypervalent Iodine Reagents [J]. Chinese Journal of Organic Chemistry, 2023, 43(11): 3784-3805.
[8]	Liu-Yang Pu, Zhiyue Li, Limin Li, Yucui Ma, Min Ma, Shengquan Hu, Zhengzhi Wu. Asymmetric Synthesis of (–)-Colchicine and Its Natural Analog (–)-N-Acetylcolchicine Methyl Ether [J]. Chinese Journal of Organic Chemistry, 2023, 43(1): 313-319.
[9]	Yuanhao Mao, Yanfeng Gao, Zhiwei Miao. Research Progress on the Asymmetric Cyclization Synthesis of Seven-Membered Rings via Transition Metal Catalysis [J]. Chinese Journal of Organic Chemistry, 2022, 42(7): 1904-1924.
[10]	Ting Yao, Jiayan Li, Jiaming Wang, Changgui Zhao. Recent Advances for the Construction of Seven-Membered Ring Catalyzed by N-Heterocyclic Carbenes [J]. Chinese Journal of Organic Chemistry, 2022, 42(4): 925-944.
[11]	Lihua Wang, Xushun Gong, Ting Lei, Shizhi Jiang. Research Progress on Asymmetric Synthesis of Flavanones [J]. Chinese Journal of Organic Chemistry, 2022, 42(3): 758-769.
[12]	Yiwen Su, Youquan Zou, Wenjing Xiao. Recent Advances in Photocatalytic Deracemization [J]. Chinese Journal of Organic Chemistry, 2022, 42(10): 3201-3212.
[13]	Xiuliang Cheng, Dong Li, Boxuan Yang, Yumei Lin, Lei Gong. Recent Advances in Visible-Light Photocatalytic Asymmetric Synthesis Enabled by Chiral Lewis Acids [J]. Chinese Journal of Organic Chemistry, 2022, 42(10): 3335-3350.
[14]	Xudong Hu, Xinliang Zhang, Wenbo Liu. Advances of Chiral Spiro Skeleton-Based Bisnitrogen Ligands in Transition-Metal Catalysis [J]. Chinese Journal of Organic Chemistry, 2022, 42(10): 3102-3117.
[15]	Haimeng Zhu, Chao Wang, Lili Zong. Progress on Biological Activity Study and Enantioselective Synthesis of Sulfoxides [J]. Chinese Journal of Organic Chemistry, 2021, 41(9): 3431-3447.

Biginelli 3,4-二氢嘧啶-2-酮衍生物的合成研究新进展

New Advances in the Synthesis of Biginelli 3,4-Dihydropyrimidin-2(1H)-one Derivatives

PDF

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments