Progress in the Synthesis of Nitrogen-containing Heterocycles by In-tramolecular Cyclization of Alkynes

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (12): 1924-1937. Previous Articles Next Articles

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炔烃分子内环化反应合成含氮杂环化合物研究进展

罗培松^a；汤日元^a；钟平^a；李金恒^*,a,b

(a温州大学化学与材料工程学院温州 325027) (b湖南师范大学化学化工学院教育部化学生物学与中药分析重点实验室长沙 410081)

收稿日期:2008-12-01 修回日期:2009-03-30 发布日期:2010-05-15
通讯作者: 李金恒 E-mail:jhli@hunnu.edu.cn
基金资助:
国家级.国家自然科学基金

Progress in the Synthesis of Nitrogen-containing Heterocycles by In-tramolecular Cyclization of Alkynes

Luo, Peisong^a；Tang, Riyuan^a；Zhong, Ping^a；Li, Jinheng^*,a,b

(^a College of Chemistry and Materials Science, Wenzhou University, Wenzhou 325027) (^b Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), Hunan Normal University, Changsha 410081)

Received:2008-12-01 Revised:2009-03-30 Published:2010-05-15

Abstract

Intramolecular cyclization between alkynes and nitrogen atom is one of the most important routes for the synthesis of nitrogen-containing heterocycles. This paper reviews recent advance in the intramolecular cyclization reactions of nitrogen with alkynes including transition metal-catalyzed intramolecular cyclization reactions and intramolecular electrophilic cyclization reactions. Moreover, mechanisms of the cyclization reactions are also described in detail.

Key words: intramolecular cyclization reaction, transition metal, electrophilic reagent, alkyne, nitrogen-containing heterocyclic compound

Cite this article

LUO Pei-Song, SHANG Ri-Yuan, ZHONG Beng, LI Jin-Heng. Progress in the Synthesis of Nitrogen-containing Heterocycles by In-tramolecular Cyclization of Alkynes[J]. Chin. J. Org. Chem., 2009, 29(12): 1924-1937.

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炔烃分子内环化反应合成含氮杂环化合物研究进展

Progress in the Synthesis of Nitrogen-containing Heterocycles by In-tramolecular Cyclization of Alkynes

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