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Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (11): 1997-2000. Previous Articles     Next Articles

Reports

N-(5-邻氯苯基-2-呋喃甲酰氨基)丙氨酰胺衍生物的合成和 生物活性测定

胥 杨; 薛思佳*; 孙晋峰; 方治坤; 尹安琴; 陈 龙   

  1. (上海师范大学生命与环境科学学院化学系 上海 200234)
  • 收稿日期:2008-02-01 修回日期:2008-04-23 发布日期:2008-11-18
  • 通讯作者: 薛思佳

Synthesis and Biological Activity of N-[5-(2-Chlorophenyl)furan-2- formylamino]alanamide Derivatives

XU, Yang; XUE, Si-Jia* ; SUN, Jin-Feng; FANG, Zhi-Kun; YIN, An-Qin ; CHEN, Long
  

  1. (a Department of Chemistry, Shanghai Normal University, Shanghai 200234)
  • Received:2008-02-01 Revised:2008-04-23 Published:2008-11-18
  • Contact: XUE, Si-Jia

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N-[5-(2-Chlorophenyl)furfuroyl]alanine was prepared by taking 5-(2-chlorophenyl)furfuroyl chloride and alanine as raw materials via a nonhomogeneous reaction. Ten unreported N-[5-(2-chloro- phenyl)furan-2-formylamino]alanamide derivatives (4a～4j) were designed and synthesized by using a DCC/DMAP coupling method with N-[5-(2-chlorophenyl)furfuroyl]alanine and 10 differently substituted anilines. The structures of the target compounds were confirmed by MS, IR, 1H NMR spectra, and elemental analysis. The preliminary biological tests show that some of the target compounds have certain herbicidal activities.

Key words: 5-(2-chlorophenyl)furfuroyl chloride, herbicidal activi, amide, derivative synthesis, alanine