Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (11): 1993-1996. Previous Articles     Next Articles

Reports

含有苯基的青蒿素类似物的合成

吴锦明 ; 李 英*   

  1. (中国科学院上海药物研究所 上海 201203)
  • 收稿日期:2007-12-04 修回日期:2008-03-11 发布日期:2008-11-18
  • 通讯作者: 李 英

Synthesis of an Artemisinin Analog with Phenyl Group

WU, Jin-Ming; LI, Ying*   

  1. (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203)

  • Received:2007-12-04 Revised:2008-03-11 Published:2008-11-18
  • Contact: LI, Ying

To inspect the antimalarial activity of artemisinin analog with a phenyl group (7), the phytooxygenation precursor 16 was synthesized from benzaldehyde via 10 reactions. However, the phytooxygenation product 17 was not the target compound 7. The structure of 17 was elucidated by X ray analysis.

Key words: artemisinin analog, phytooxygenation, X ray analys, synthesis