Rapid and Efficient Synthesis of Ester-Type Molecular Tweezers Derived from Hyodeoxycholic Acid in Solvent-Free  Conditions under Microwave Irradiation

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (06): 956-961. Previous Articles Next Articles

Original Articles

微波促进无溶剂条件下酯键型猪去氧胆酸分子钳的快速有效合成

吴秀明; 赵志刚*; 刘兴利 ; 陈宇; 赵潇湘

(西南民族大学化学与环境保护工程学院成都 610041)

收稿日期:2008-12-21 修回日期:2009-03-10 发布日期:2009-06-20
通讯作者: 赵志刚

Rapid and Efficient Synthesis of Ester-Type Molecular Tweezers Derived from Hyodeoxycholic Acid in Solvent-Free Conditions under Microwave Irradiation

Wu, Xiuming; Zhao, Zhigang* ; Liu, Xingli; Chen, Yu; Zhao, Xiaoxiang

(College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041)

Received:2008-12-21 Revised:2009-03-10 Published:2009-06-20
Contact: Zhao, Zhigang

Abstract

Eleven molecular tweezer artificial receptors based on hyodeoxycholic acid have been synthesized by using solid K2CO3 as supporter through the reaction of methyl hyodeoxycholate with aroyl chloride in solvent-free conditions under microwave irradiation. The structures of all the molecular tweezers were characterized by 1H NMR, IR, mass spectra and elemental analysis. Compared with the conventional method, this method is simple, rapid, efficient and eco-friendly. The re-cognition properties of these molecular tweezers for aromatic amines and chiral mole-ules were investigated. The results indicate that these molecular tweezers not only recognize aromatic amines molecules well but also have good enantioselectivity to D/L-amino acid methyl esters.

Key words: molecular tweezer, microwave irradiation, molecular recognition, hyodeoxycholic acid

Cite this article

Wu, Xiuming; Zhao, Zhigang* ; Liu, Xingli; Chen, Yu; Zhao, Xiaoxiang. Rapid and Efficient Synthesis of Ester-Type Molecular Tweezers Derived from Hyodeoxycholic Acid in Solvent-Free Conditions under Microwave Irradiation[J]. Chin. J. Org. Chem., 2009, 29(06): 956-961.

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微波促进无溶剂条件下酯键型猪去氧胆酸分子钳的快速有效合成

Rapid and Efficient Synthesis of Ester-Type Molecular Tweezers Derived from Hyodeoxycholic Acid in Solvent-Free Conditions under Microwave Irradiation

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