Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (06): 993-997. Previous Articles     Next Articles

Reports

吲哚-6-酰腙类化合物的微波合成及其抗菌活性研究

叶 英; 赵志刚*; 刘兴利; 李清寒   

  1. (西南民族大学化学与环境保护工程学院 成都 610041)
  • 收稿日期:2008-12-11 修回日期:2009-03-28 发布日期:2009-06-20
  • 通讯作者: 赵志刚

Microwave-Assisted Synthesis of Indole-6-acylhydrazone and Their Antibacterial Activities

Ye, Ying; Zhao, Zhigang*; Liu, Xingli; Li, Qinghan   

  1. (College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041)
  • Received:2008-12-11 Revised:2009-03-28 Published:2009-06-20
  • Contact: Zhao, Zhigang

A novel type of indole-6-acylhydrazone compounds have been designed and synthesized by connecting the structure of acylhydrazone to indole ring, with a view of providing lead compounds for the screening of new dugs. Fourteen new compounds have been obtained with high yields under the conditions of microwave irradiation, and the structures of all new compounds were characterized by 1H NMR, IR, MS techniques and elemental analysis. Their antibacterial activities have been tested against three kinds of bacteria. The preliminary results show that the compounds possess different inhibitive effects.

Key words: acylhydrazone, antibacterial activity, microwave irradiation, indole