Fluoroorganic compounds, especially chiral fluorinated compounds, are of importance in the pharmaceutical and agrochemical industries as well as in the development of functional materials and related areas. It has been a challenge for organic chemists to enantioselectively introduce a fluorine atom into one molecule. In recent years, enantioselective fluorinations have made significant progresses under chemists’ continuous efforts. Chiral nonracemic fluoro-organic molecules with a fluorine atom on a stereogenic center are readily prepared via chiral electrophilic fluorinating reagent-mediated enantioselective fluorinations, substrate-controlled enantioselective electrophilic fluorinations, chiral metal complexes and asymmetric catalyst—directed catalytic enantioselective fluorinations. Especially, chiral metal complexes and organo-catalysts in combination with electrophilic fluorinating reagents have found applications to the synthesis of a variety of chiral fluoroorganic compounds. This review will cover in detail the methods, strategies and re-cent developments in enantioselective electrophilic fluorinations, and discuss their applications and limita-tions of these asymmetric fluorination methods.

Key words: enantioselective fluorination, chiral auxiliary, organocatalysis, asymmetric catalysis, electrophilic fluorination