Synthesis of 5-Substituted-2-thiohydantoin Derivatives un-derMicrowave Irradiation

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (2): 228-233. Previous Articles Next Articles

Original Articles

微波辐射下5-取代-2-硫代海因衍生物的合成

周佳栋，曹飞*，武红丽，韦萍

(南京工业大学制药与生命科学学院南京 210009)

收稿日期:2007-01-17 修回日期:2007-06-20 发布日期:2008-02-01
通讯作者: 曹飞

Synthesis of 5-Substituted-2-thiohydantoin Derivatives un-derMicrowave Irradiation

ZHOU Jia-Dong,CAO Fei*,WU Hong-Li,WEI Ping

(College of Life Science and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009)

Received:2007-01-17 Revised:2007-06-20 Published:2008-02-01
Contact: CAO Fei

Abstract

Eleven 5-substituted-2-thiohydantoin derivatives were synthesized by a two-step reaction of ammonium thiocyanate with α-amino acids under microwave irradiation. The structures of intermediate products and final products were characterized by ¹H NMR, IR spectra and elemental analysis. Compared with conventional heating method, microwave irradiation possessed such advantages as short reaction time (4 min), high yield of each step (85%～93%). In the meantime, the reaction course of synthesis of compound 2h was discussed.

Key words: 5-substituted-1-acetyl-2-thiohydantoin, 5-substituted-2-thiohydantoin, ammonium thiocyanate, microwave irradiation, α-amino acid

Cite this article

ZHOU Jia-Dong,CAO Fei*,WU Hong-Li,WEI Ping. Synthesis of 5-Substituted-2-thiohydantoin Derivatives un-derMicrowave Irradiation[J]. Chin. J. Org. Chem., 2008, 28(2): 228-233.

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微波辐射下5-取代-2-硫代海因衍生物的合成

Synthesis of 5-Substituted-2-thiohydantoin Derivatives un-derMicrowave Irradiation

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