Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (04): 347-354.     Next Articles

Review

仿生催化剂——Salen金属络合物催化不对称环氧化烯烃的基础

周智明*,李连友,徐巧,余从煊   

  1. (北京理工大学化工与环境学院 北京 100081)
  • 收稿日期:2003-12-11 修回日期:2004-09-10 发布日期:2005-03-30
  • 通讯作者: 周智明

Bionic Catalyst: Salen-metal Complex Catalyzed Asymmetric Epoxidation of the Olefins

ZHOU Zhi-Ming*,LI Lian-You,XU Qiao,YU Cong-Xuan   

  1. (School of Chemical Engineering & the Environment, Beijing Institute of Technology, Beijing 100081)
  • Received:2003-12-11 Revised:2004-09-10 Published:2005-03-30
  • Contact: ZHOU Zhi-Ming

The salen and porphyrin have the similar structures and properties, and salen-M and metalloporphyrin complexes have also the similarities. In this review, the salen-M complex was crowned as a bionic catalyst. It is believed that effective stereochemical communication between substrate and enzyme is essential for attaining high enantioselectivity in asymmetric reaction, and most of the successful salen-M catalysts also operate on this principle. According to these, salen-M complex catalyzed asymmetric epoxidation for olefins was discussed in detail, and the linear relationship between enantioselectivities and 5,5'-substituen effect on salen was developed. Moreover, enantioselectivities were still related to the structure of the salen-M complexes and substrates, as well as the reaction conditions.

Key words: salen-M complex, enzyme, enantioselectivity