Chin. J. Org. Chem. ›› 1997, Vol. 17 ›› Issue (6): 547-550. Previous Articles     Next Articles

Original Articles

7,8-二氢-6,6-二甲基-7,8-环氧-6氢-吡喃[2,3-f]苯并-2,1,3-恶二唑的合成

孙宏斌;华维一;陈玲;彭司勋   

  1. 中国药科大学药物化学研究室
  • 发布日期:1997-12-25

Synthesis of 7,8-dihydro-6,6-dimethyl-7,8-epoxy-6H-pyrano[2,3-f] benzo-2,1,3-oxadiazole

SUN HONGBIN;HUA WEIYI;CHEN LING;PENG SIXUN   

  • Published:1997-12-25

A practical procedure for the synthesis of 7,8-dihydro-6,6-dimethyl- 7,8-epoxy-6H-pyrano[2,3-f]benzo-2,1,3-oxadiazole, the key intermediate for the synthesis of a series of potassium channel openers related to NIP-121 (compound 1), has been developed which involved the catalytic epoxidation of benzfurazan derivative 12.

Key words: NITRATION, ACETAMIDO GROUP, REDUCTION REACTION, EPOXIDATION REACTION, FRIES REARRANGEMENT, ORGANIC SYNTHESIS, DEHYDRATION REACTION, ESTERIFICATION, BENZOPYRAN P, ANTIHYPERTENSIVE AGENTS

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