Baylis-Hillman Reactions in Non-traditional Media

Abstract

The Baylis-Hillman reaction, a carbon-carbon bond forming reaction, is one of the very few reactions wherein atom economy is perfectly preserved. The Baylis-Hillman adducts have versatile functionality thus making this reaction as an efficient synthetic method for the construction of multifunctional molecules. However, the B-H reaction often suffers from being inconveniently slow and low yields. To overcome these problems, several novel solvent media have been attempted. This paper reviews the recent advances and the developing trend in these fields.

Key words: ionic liquid, supercritical carbon dioxide, water, Baylis-Hillman reaction

Cite this article

ZHAO San-Hu*^,a,ZHAO Ming-Gen^a,ZHANG Hai-Rong^a,CHEN Zhao-Bin^{b. Baylis-Hillman Reactions in Non-traditional Media[J]. Chin. J. Org. Chem., 2007, 27(03): 322-328.}

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非传统介质中的Baylis-Hillman反应